Lead exposure aggravates calcium oxalate crystal-induced renal injury and inflammation by upregulating IRF7 and promoting M1 macrophage polarization
Our results suggested that Pb exposure can aggravate CaOx-induced renal injury and inflammatory response by regulating IRF7 expression and M1 macrophage polarization. This provided new perspectives for the prevention and treatment of nephrocalcinosis.
Authors
- Bingbing Hou (ORCID: https://orcid.org/0000-0002-5352-1622)
- Jie Yu (ORCID: https://orcid.org/0000-0002-7401-7580)
- Zongyao Hao (ORCID: https://orcid.org/0000-0003-3399-3689)
- Qingfeng Huang (ORCID: https://orcid.org/0000-0002-7334-570X)
- Yuexian Xu (ORCID: https://orcid.org/0000-0003-0986-5505)
- Qiao Qi
- Yang Chen (ORCID: https://orcid.org/0000-0003-2641-6146)
Institutions
- Anhui Medical University (CN)
- First Affiliated Hospital of Anhui Medical University (CN)
Publication Details
- Journal
- Ecotoxicology and Environmental Safety
- Published
- 2025-12-11
- DOI
- https://doi.org/10.1016/j.ecoenv.2025.119557
- Citations
- 1
- Primary Topic
- Heavy Metal Exposure and Toxicity
- Type
- article
- Field-Weighted Citation Impact
- 1.20