Blood RNA biomarkers and a point-of-care elastase assay for detecting host immune activation in suspected sepsis: Trajectory matters
Patients progressing to more severe forms of sepsis did not have higher absolute levels of neutrophil activation RNA biomarkers (or higher bacterial burden in blood) compared to patients with sepsis. However, a change in RNA biomarkers or elastase between zero and three hours was strongly indicative of progression to more severe forms of sepsis.
Authors
- Eduard Shaykhinurov (ORCID: https://orcid.org/0000-0001-9506-4039)
- Andrew C. Meltzer (ORCID: https://orcid.org/0000-0001-5971-8314)
- John Lafleur (ORCID: https://orcid.org/0000-0003-4404-2723)
- Zachary Falk (ORCID: https://orcid.org/0000-0002-8811-5798)
- Avery League
- Tisha Jepson
- Ryan Heidish (ORCID: https://orcid.org/0000-0003-3749-9370)
- Michael R. Hayden (ORCID: https://orcid.org/0000-0001-5159-1419)
- Timothy A. McCaffrey (ORCID: https://orcid.org/0000-0002-4648-7833)
- Daniel King
- Richard Wargowsky (ORCID: https://orcid.org/0000-0003-1279-4875)
- Mary Pasquale (ORCID: https://orcid.org/0000-0003-0258-7194)
- Kevin Jaatinen (ORCID: https://orcid.org/0000-0003-0010-8970)
- Aditya Maddali
- David Yamane (ORCID: https://orcid.org/0000-0002-5101-2162)
- Taylor Bolden
- Akhil Patel
- Aditya Loganathan (ORCID: https://orcid.org/0000-0001-7533-9285)
- Jennifer Goldman (ORCID: https://orcid.org/0000-0003-2651-8767)
- Grace Holloway (ORCID: https://orcid.org/0009-0006-0823-5076)
- J. F. Perkins
- Soroush Shahamatdar
- Tarun Loganathan
Institutions
- George Washington University (US)
- Washington University Medical Center (US)
Publication Details
- Journal
- PLoS ONE
- Published
- 2025-12-12
- DOI
- https://doi.org/10.1371/journal.pone.0338012
- Primary Topic
- Sepsis Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Institutes of Health