Ultrastaging Confirms the Superior Sensitivity of Quantitative Immunocytology for Detection of Lymph Node Spread in Non–Small Cell Lung Cancer Patients
Routine histopathologic workup underestimates LN spread in NSCLC patients and occasionally misses even macrometastases. US confirms and validates the significantly higher sensitivity of IC over routine histopathologic workup. In particular, IC has the potential to improve appropriate staging and prognostic stratification of patients in the future.
Authors
- Patricia Segschneider
- Felix Elsner (ORCID: https://orcid.org/0009-0006-5805-082X)
- Zsolt Sziklavári (ORCID: https://orcid.org/0000-0002-7416-5233)
- Tobias Robold
- Florian Weber (ORCID: https://orcid.org/0000-0001-7480-8828)
- Bernhard Polzer (ORCID: https://orcid.org/0000-0002-3797-9975)
- Christoph A. Klein (ORCID: https://orcid.org/0000-0001-7128-1725)
- Anthea Povall
- Jozef Zustin (ORCID: https://orcid.org/0000-0002-9217-466X)
- Petra Rümmele
- Arndt Hartmann
- H Hofmann
- Natascha Leicht
- Iris Nun
Institutions
- University Hospital Regensburg (DE)
- Universitätsklinikum Erlangen (DE)
- Fraunhofer Institute for Toxicology and Experimental Medicine (DE)
- Krankenhaus Barmherzige Brüder (DE)
- Klinikum Coburg (DE)
- Praxis für Humangenetik (DE)
- Hartmann Group (Germany) (DE)
- Paul Gerhardt Diakonie (DE)
- Comprehensive Cancer Center Erlangen (DE)
- University of Regensburg (DE)
Publication Details
- Journal
- Archives of Pathology & Laboratory Medicine
- Published
- 2025-12-12
- DOI
- https://doi.org/10.5858/arpa.2025-0162-oa
- Primary Topic
- Lung Cancer Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00