Mechanistic study of HIF-1α-mediated regulation of the Notch1 pathway in promoting radioresistance in head and neck squamous cell carcinoma: a comprehensive analysis based on bioinformatics and functional experiments
Our findings suggest that HIF-1α promotes radiotherapy resistance in HNSCC by activating the Notch1 signaling axis. Targeting this pathway may enhance radiosensitivity and provide a new strategy for overcoming hypoxia-driven resistance.
Authors
- Rui Bao (ORCID: https://orcid.org/0000-0002-5826-2316)
- Junhua Liao (ORCID: https://orcid.org/0000-0001-8160-7688)
Institutions
- University of Bonn (DE)
- Université Paris Dauphine-PSL (FR)
Publication Details
- Journal
- BMC Cancer
- Published
- 2025-12-12
- DOI
- https://doi.org/10.1186/s12885-025-15428-7
- Primary Topic
- Cancer, Hypoxia, and Metabolism
- Type
- article
- Field-Weighted Citation Impact
- 0.00