Case series of de novo occurrence of Graves’ disease following thermal ablation for benign thyroid nodules: an uncommon event that should be considered
Although rare, GD may develop following TA, likely through immune activation triggered by thyroid tissue injury in genetically predisposed individuals. Routine TRAb screening before TA is not currently justified; however, clinical awareness is essential to distinguish transient post-ablation thyrotoxicosis from true GD and to ensure timely initiation of antithyroid therapy when appropriate. Despite these rare cases, the overall incidence remains very low, confirming the excellent safety profile of TA for benign thyroid nodules.
Authors
- Laura Croce (ORCID: https://orcid.org/0000-0001-7668-8276)
- Marsida Teliti (ORCID: https://orcid.org/0009-0007-4606-8923)
- Mario Rotondi (ORCID: https://orcid.org/0000-0001-6464-2334)
- Spyridon Chytiris (ORCID: https://orcid.org/0000-0002-7999-3505)
- Francesca Coperchini (ORCID: https://orcid.org/0000-0002-4845-8630)
- Flavia Magri (ORCID: https://orcid.org/0000-0003-4846-9847)
- Beatrice Grillini
- Isabella Chiardi (ORCID: https://orcid.org/0009-0009-2327-1659)
Institutions
- University of Pavia (IT)
- Istituti Clinici Scientifici Maugeri (IT)
Publication Details
- Journal
- European Thyroid Journal
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1530/etj-25-0205
- Primary Topic
- Thyroid Cancer Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00