Risk Factors Influencing Survival in T‐Cell Lymphoblastic Lymphoma and T‐Cell Acute Lymphoblastic Leukemia
In this multicenter retrospective analysis, hematopoietic stem-cell transplantation (allo- or auto-HSCT) was associated with better survival than chemotherapy alone. For T-LBL, an exploratory signal from our prognostic model suggests that selected high-risk patients may be considered for upfront allo-HSCT. However, overall survival was comparable between allo- and auto-HSCT in this cohort, and durable outcomes after transplant were largely observed in patients who achieved complete remission. These findings are hypothesis-generating and support individualized, response-adapted strategies that warrant prospective validation.
Authors
- Jong Hyuk Lee (ORCID: https://orcid.org/0000-0001-8465-2791)
- Young‐Woo Jeon (ORCID: https://orcid.org/0000-0003-3362-8200)
- Seoree Kim (ORCID: https://orcid.org/0000-0001-7461-103X)
- Seok Lee
- Kyoung Il Min (ORCID: https://orcid.org/0000-0002-8089-3800)
- Seok‐Goo Cho (ORCID: https://orcid.org/0000-0002-5429-4839)
- Jae‐Ho Yoon (ORCID: https://orcid.org/0000-0002-2145-9131)
- Gi June Min (ORCID: https://orcid.org/0000-0001-7636-4693)
- Hye Sung Won (ORCID: https://orcid.org/0000-0002-5134-4538)
- Byung‐Su Kim (ORCID: https://orcid.org/0000-0003-4014-9400)
- Ki‐Seong Eom (ORCID: https://orcid.org/0000-0002-0578-126X)
- Tong Yoon Kim (ORCID: https://orcid.org/0000-0002-9559-992X)
- Joon Won Jeoung
Institutions
- St. Mary's Hospital (US)
- The Catholic University of Korea Incheon St. Mary's Hospital (KR)
- The Catholic University of Korea Uijeongbu St. Mary's Hospital (KR)
- The Catholic University of Korea Yeouido St. Mary's Hospital (KR)
- St. Mary's Hospital (US)
- St Mary's Hospital (GB)
- The Catholic University of Korea Bucheon St. Mary's Hospital (KR)
- St. Mary’s Hospital (ZA)
- St. Mary's Hospital (US)
- The Catholic University of Korea Seoul St. Mary's Hospital (KR)
- Catholic University of Korea (KR)
Publication Details
- Journal
- Cancer Medicine
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/cam4.71365
- Primary Topic
- Acute Lymphoblastic Leukemia research
- Type
- article
- Field-Weighted Citation Impact
- 0.00