Enhanced detection of bacterial etiologies, antibiotic resistance profile, and treatment outcomes of meningitis patients in Ethiopia: a prospective cross-sectional study
PCR significantly outperformed culture in detecting bacterial pathogens. E. coli was the most common causative agent of bacterial meningitis, and we observed high rates of antibiotic resistance among Gram-negative bacteria. While most patients had favorable outcomes, low Glasgow Coma Scale scores, comorbidities, and delayed presentation to healthcare facilities were independently associated with unfavorable outcomes.
Authors
- Getachew Tesfaye Beyene (ORCID: https://orcid.org/0000-0001-7273-7333)
- Aschalew Gelaw (ORCID: https://orcid.org/0000-0001-9239-1616)
- Andargachew Mulu (ORCID: https://orcid.org/0000-0003-2862-0175)
- Jurjan Aman (ORCID: https://orcid.org/0000-0001-6211-1791)
- Dawit Hailu Alemayehu (ORCID: https://orcid.org/0000-0002-4118-8260)
- Alem Abrha Kalayu (ORCID: https://orcid.org/0000-0002-5170-4898)
- Ashenafi Alemu Wami
- Adane Mihret
- Seifegebriel Teshome
- Derso Wale Mesele
- Lema Ayele
Institutions
- Madda Walabu University (ET)
- Wolkite University (ET)
- Asossa University (ET)
- Armauer Hansen Research Institute (ET)
- Arsi University
- Addis Ababa University (ET)
- University of Gondar (ET)
Publication Details
- Journal
- BMC Microbiology
- Published
- 2025-12-12
- DOI
- https://doi.org/10.1186/s12866-025-04569-1
- Primary Topic
- Bacterial Infections and Vaccines
- Type
- article
- Field-Weighted Citation Impact
- 0.00