Network dysfunction underlying verbal fluency deficits in newly diagnosed epilepsy: a resting-state fMRI functional connectivity study
These findings indicate that NDE patients exhibit widespread dysfunction in perceptual networks. Abnormal FC of IFG and STG within the left auditory network serves as a neural substrate linking seizure burden to verbal fluency deficits. These insights provide a foundation for future interventions targeting network-level dysfunction in patients with epilepsy.
Authors
- Xiuli Li (ORCID: https://orcid.org/0000-0003-3377-892X)
- Qiyong Gong (ORCID: https://orcid.org/0000-0002-5912-4871)
- Ge Tan (ORCID: https://orcid.org/0000-0003-0391-4548)
- Deng Chen (ORCID: https://orcid.org/0000-0002-9087-9885)
- Yingchun Xu (ORCID: https://orcid.org/0000-0001-5763-7297)
- Fangzhou Liu (ORCID: https://orcid.org/0000-0002-9782-8212)
- Ling Liu (ORCID: https://orcid.org/0000-0003-0927-6372)
- Ping Jiang (ORCID: https://orcid.org/0000-0003-2429-3285)
- Zixian Zhou
Institutions
- Xiamen University (CN)
- Sichuan University (CN)
- West China Medical Center of Sichuan University (CN)
- West China Hospital of Sichuan University (CN)
- Zhongshan Hospital of Xiamen University (CN)
Publication Details
- Journal
- BMC Medicine
- Published
- 2025-12-13
- DOI
- https://doi.org/10.1186/s12916-025-04577-y
- Primary Topic
- Functional Brain Connectivity Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00