Inflammasome activation contributes to cisplatin resistance in ovarian cancer
Our findings suggest that inflammasome activation and pyroptosis are mechanisms associated with ovarian cancer chemoresistance to CDDP, contributing to the devastating scenario of this disease. Targeting the NLRP1 and NLRP3 pathways could represent a promising strategy to improve OC treatment.
Authors
- Josiany Carlos de Souza (ORCID: https://orcid.org/0000-0001-6777-0227)
- Tatiana Massariol Pimenta (ORCID: https://orcid.org/0000-0003-0647-3303)
- Letícia Batista Azevedo Rangel (ORCID: https://orcid.org/0000-0002-6150-4064)
- Bárbara da Silva Martins (ORCID: https://orcid.org/0000-0002-6240-8023)
- Solenny Maria Silva Butzene
- José Matheus Simões Padilha
- Milleny Ganho Marçal
Institutions
- Harvard University (US)
- Instituto Federal do Espírito Santo (BR)
- Universidade Federal do Espírito Santo (BR)
Publication Details
- Journal
- Journal of Ovarian Research
- Published
- 2025-12-12
- DOI
- https://doi.org/10.1186/s13048-025-01852-7
- Primary Topic
- Inflammasome and immune disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Harvard University
- Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
- Conselho Nacional de Desenvolvimento Científico e Tecnológico
- Fundação de Amparo à Pesquisa e Inovação do Espírito Santo
- National Cancer Institute