Integrated phenotypic and proteomic screening identifies top‐tier Alzheimer's disease therapeutic targets
A screening platform was created to identify the most potent targets from nominated hypotheses. Integrated analysis of cellular proteomics and assay phenotypes was performed. Targets capable of reversing disease-associated proteomic signal were identified. The most impactful targets were strongly implicated in Alzheimer's disease pathogenesis.
Authors
- Ranjita Betarbet (ORCID: https://orcid.org/0000-0002-4792-8952)
- Carolyn Paisie (ORCID: https://orcid.org/0000-0003-4306-4154)
- Nicholas T. Seyfried (ORCID: https://orcid.org/0000-0002-4507-624X)
- Allan I. Levey (ORCID: https://orcid.org/0000-0002-3153-502X)
- Yuhong Du (ORCID: https://orcid.org/0000-0001-5073-2048)
- Gregory W. Carter (ORCID: https://orcid.org/0000-0002-2834-8186)
- Jesse C. Wiley (ORCID: https://orcid.org/0000-0002-1430-772X)
- Gregory A. Cary (ORCID: https://orcid.org/0000-0003-3573-5229)
- Elizabeth Zoeller (ORCID: https://orcid.org/0000-0001-9588-3114)
- Duc Minh Duong (ORCID: https://orcid.org/0000-0001-5880-1888)
- Haian Fu (ORCID: https://orcid.org/0000-0002-2362-7979)
- Qianjin Li
Institutions
- University of Kansas (US)
- Emory University (US)
- Jackson Laboratory (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz.71008
- Primary Topic
- Alzheimer's disease research and treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00