STAT4 gene polymorphism promotes progression of rheumatoid arthritis

Our study concluded that STAT4 gene polymorphism (SNPs: rs11889341, rs10181656 and rs7574865) were associated with RA development in Iraqi population. Furthermore, the SNPs (rs11889341 and rs7574865) were related to family history, RF and Anti-CCP, while SNP (rs10181656) didn't display any relation among studied population.

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Publication Details

Journal
Journal of Genetic Engineering and Biotechnology
Published
2025-10-15
DOI
https://doi.org/10.1016/j.jgeb.2025.100589
Primary Topic
Rheumatoid Arthritis Research and Therapies
Type
article
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article

STAT4 gene polymorphism promotes progression of rheumatoid arthritis

Rana Talib Al-Muswie, Usama Al-Sari, Lee Suan Chua, Anwar Madlool Al-janabi et al.
Journal of Genetic Engineering and Biotechnology
Rheumatoid Arthritis Research and Therapies
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STAT4 gene polymorphism promotes progression of rheumatoid arthritis

Rana Talib Al-Muswie, Usama Al-Sari, Lee Suan Chua, Anwar Madlool Al-janabi, Dawood Ali Salim Dawood, Samer Alwazni
article en

Abstract

Our study concluded that STAT4 gene polymorphism (SNPs: rs11889341, rs10181656 and rs7574865) were associated with RA development in Iraqi population. Furthermore, the SNPs (rs11889341 and rs7574865) were related to family history, RF and Anti-CCP, while SNP (rs10181656) didn't display any relation among studied population.

Journal of Genetic Engineering and BiotechnologyVol. 23(4)
Thi Qar University (IQ), University of Wasit (IQ), University of Technology Malaysia (MY), University of Kufa (IQ)
Openalex Percentile: Top 43%
Rheumatoid Arthritis Research and Therapies
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