Cardiorespiratory cross‐frequency coupling biomarker for sudden unexpected death in epilepsy
Ictal ECG-based PAC analysis is a potential noninvasive biomarker for SUDEP risk, capturing cardiorespiratory dysregulation during seizures. Its integration into wearable ECG devices could enable real-time risk assessment, informing clinical interventions such as rescue medications, antiseizure medication adjustments, or surgical evaluations.
Authors
- Berj L. Bardakjian (ORCID: https://orcid.org/0000-0001-9969-4775)
- Orrin Devinsky (ORCID: https://orcid.org/0000-0003-0044-4632)
- Juliana Laze
- Peter L. Carlen (ORCID: https://orcid.org/0000-0002-3339-8102)
- Yotin Chinvarun (ORCID: https://orcid.org/0000-0003-3630-5423)
- Victor Lira (ORCID: https://orcid.org/0000-0003-0236-4361)
- Adam C. Gravitis (ORCID: https://orcid.org/0000-0001-9178-5496)
- Richard Wennberg (ORCID: https://orcid.org/0000-0002-1865-2280)
Institutions
- University of Toronto (CA)
- Phramongkutklao Hospital (TH)
- New York University (US)
Publication Details
- Journal
- Epilepsia
- Published
- 2025-12-13
- DOI
- https://doi.org/10.1002/epi.70057
- Citations
- 1
- Primary Topic
- Epilepsy research and treatment
- Type
- article
- Field-Weighted Citation Impact
- 1.47