Genomic platform specific polygenic risk scores impact breast cancer risk stratification
Our findings demonstrate that platform-specific variability can influence PRS<sub>313</sub> estimates to potentially reclassify individuals around clinically relevant thresholds.
Authors
- Mikael Hartman (ORCID: https://orcid.org/0000-0001-5726-9965)
- Iain Beehuat Tan (ORCID: https://orcid.org/0000-0003-4951-0354)
- Jingmei Li (ORCID: https://orcid.org/0000-0001-8587-7511)
- Pierre-Alexis Goy (ORCID: https://orcid.org/0000-0002-0281-0889)
- Rajkumar Dorajoo (ORCID: https://orcid.org/0000-0001-6608-2051)
- Liuh Ling Goh (ORCID: https://orcid.org/0000-0002-1387-3682)
- Elaine Ah‐Gi Lo (ORCID: https://orcid.org/0000-0001-9241-9236)
- Weang-Kee Ho (ORCID: https://orcid.org/0000-0002-8269-7344)
- Dawn Q. Chong (ORCID: https://orcid.org/0000-0002-8293-4493)
- Joanna Tan (ORCID: https://orcid.org/0009-0004-1712-711X)
- Alexis Jiaying Khng (ORCID: https://orcid.org/0000-0003-1004-6048)
- Hwee Lin Wee (ORCID: https://orcid.org/0000-0002-7150-1801)
- Peh Joo Ho (ORCID: https://orcid.org/0000-0002-3017-4023)
- Nicolas Bertin (ORCID: https://orcid.org/0000-0002-9835-9606)
- Zheng Li (ORCID: https://orcid.org/0000-0002-7060-2213)
- Kayla Aisha Kamila
Institutions
- Agency for Science, Technology and Research (SG)
- University of Nottingham Malaysia Campus (MY)
- SingHealth (SG)
- National University of Singapore (SG)
- Tan Tock Seng Hospital (SG)
- Cancer Research Malaysia (MY)
- Duke-NUS Medical School (SG)
- National Cancer Centre Singapore (SG)
- National University Hospital (SG)
- National University Health System (SG)
- Genome Institute of Singapore (SG)
Publication Details
- Journal
- Communications Medicine
- Published
- 2025-12-12
- DOI
- https://doi.org/10.1038/s43856-025-01298-4
- Primary Topic
- Genetic Associations and Epidemiology
- Type
- article
- Field-Weighted Citation Impact
- 0.00