Association between the gut microbiome and neurodevelopmental outcomes in infants with congenital heart disease: A prospective cohort study
Children with congenital heart disease with lower cognitive and language scores had lower diversity and less anti-inflammatory flora (eg, Bifidobacterium), whereas those with lower motor scores had a higher abundance of pro-inflammatory flora (eg, Serratia, Acinetobacter, and Proteus). Further studies are needed to understand the longitudinal effect of gut microbial dysbiosis on neurodevelopment in children with congenital heart disease.
Authors
- Patricia W. Denning
- Christina Calamaro
- Amelia St. John
- Nneka Alexander
- Ann‐Marie Brown (ORCID: https://orcid.org/0000-0002-2905-6353)
- Michael P. Fundora (ORCID: https://orcid.org/0000-0003-3204-1176)
- Scott E. Gillespie (ORCID: https://orcid.org/0000-0003-1295-3602)
- Jinbing Bai (ORCID: https://orcid.org/0000-0001-6726-5714)
- Hui Huang (ORCID: https://orcid.org/0009-0005-2490-9985)
- Rachael Keiffer
- Kolby Sanders-Lewis
- Lily Dressner
Institutions
- Emory University (US)
- Children's Healthcare of Atlanta (US)
Publication Details
- Journal
- Journal of Parenteral and Enteral Nutrition
- Published
- 2025-12-12
- DOI
- https://doi.org/10.1002/jpen.70038
- Primary Topic
- Gut microbiota and health
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Emory University
- Georgia Clinical and Translational Science Alliance
- National Institutes of Health
- School of Medicine, Emory University