Nocturnal melatonin secretion and risk of type 2 diabetes: a prospective cohort study
Low nocturnal melatonin secretion was independently associated with a higher incidence of T2D in adults. A key limitation is the reliance on a single morning urine sample to estimate melatonin secretion. The findings support circadian regulation as a determinant of metabolic health and warrant further investigation of melatonin pathways in diabetes prevention.
Authors
- Sofia Enhörning (ORCID: https://orcid.org/0000-0001-8895-0534)
- Simon Timpka (ORCID: https://orcid.org/0000-0001-7445-7212)
- Peter M. Nilsson (ORCID: https://orcid.org/0000-0002-5652-8459)
- Mats Pihlsgård (ORCID: https://orcid.org/0000-0002-3934-9387)
- Einar Smith (ORCID: https://orcid.org/0000-0002-4150-2459)
- Anna Franzén
Institutions
- Malmö University (SE)
- Lund University (SE)
- Skåne University Hospital (SE)
Publication Details
- Journal
- The Journal of Clinical Endocrinology & Metabolism
- Published
- 2025-12-12
- DOI
- https://doi.org/10.1210/clinem/dgaf667
- Primary Topic
- Circadian rhythm and melatonin
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Svenska Sällskapet för Medicinsk Forskning
- Vetenskapsrådet
- Direktör Albert Påhlssons Stiftelse
- Svenska Läkaresällskapet
- Skånes universitetssjukhus