Enrichment of patients with concomitant limbic‐predominant age‐related TDP‐43 encephalopathy (LATE) on the Alzheimer's disease continuum using hippocampal volume
Quartiles of HVs stratify CI individuals. Approach distinguishes suspected AD+sLATE-, AD-sLATE+, and AD+sLATE+ subgroups. The method is simple, scalable, and requires no complex modeling or biomarker panels. It enables practical identification of mixed pathology in clinical settings. It supports trial enrichment by excluding or targeting mixed pathology cases.
Authors
- James C. Gee (ORCID: https://orcid.org/0000-0002-2258-0187)
- Long Xie (ORCID: https://orcid.org/0000-0002-7184-7028)
- Philip A. Cook (ORCID: https://orcid.org/0000-0002-1985-8475)
- S. J. Wolk (ORCID: https://orcid.org/0000-0002-0826-9261)
- Niyousha Sadeghpour (ORCID: https://orcid.org/0000-0001-8665-0335)
- Sandhitsu R. Das (ORCID: https://orcid.org/0000-0003-0530-2887)
- Nidhi S. Mundada (ORCID: https://orcid.org/0000-0003-3108-6751)
- Paul A. Yushkevich (ORCID: https://orcid.org/0000-0001-8543-4016)
- Xueying Lyu (ORCID: https://orcid.org/0000-0002-2885-3940)
- Christopher Brown (ORCID: https://orcid.org/0000-0003-2057-3976)
- Emily McGrew
Institutions
- University of Pennsylvania (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz.70970
- Primary Topic
- Dementia and Cognitive Impairment Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Alzheimer's Association
- Alzheimer's Disease Neuroimaging Initiative
- National Institutes of Health