Mechanosensitive Yes-Associated Protein/TAZ–cGAS–STING Axis Induces Periodontal Ligament Fibroblasts Senescence and Mediates Compression-Induced Root Resorption
Mechanical stress-induced YAP dysfunction drives PDLF senescence via cGAS/STING pathway activation, establishing a novel mechanobiological axis in root resorption.
Authors
- Zuping Wu (ORCID: https://orcid.org/0000-0003-3661-8593)
- Siqi Bao (ORCID: https://orcid.org/0000-0002-0455-4399)
- Qianming Chen (ORCID: https://orcid.org/0000-0002-5371-4432)
- Lu Xiao
- Xiaoyan Chen (ORCID: https://orcid.org/0000-0002-3143-8158)
- Qian Chen (ORCID: https://orcid.org/0000-0001-7265-9806)
- Guiwen Guan (ORCID: https://orcid.org/0009-0006-3688-6829)
- Ruifeng Song
Institutions
- Guangxi Medical University (CN)
- Zhejiang Cancer Hospital (CN)
- Zhejiang University Medical College Affiliated Stomatological Hospital (CN)
- Stomatology Hospital (CN)
- Case Western Reserve University (US)
- Zhejiang University (CN)
Publication Details
- Journal
- International Dental Journal
- Published
- 2025-12-11
- DOI
- https://doi.org/10.1016/j.identj.2025.109303
- Primary Topic
- interferon and immune responses
- Type
- article
- Field-Weighted Citation Impact
- 0.00