Dinutuximab Beta Added to Temozolomide-Based Chemotherapy for Children With Relapsed and Refractory Neuroblastoma: Results of the ITCC-SIOPEN BEACON Immuno Phase II Trial
Within a randomized phase II setting, results observed with addition of dB to T-based chemotherapy in RR-HR-NB warrant further evaluation.
Authors
- Dave Hobin
- Nadège Corradini (ORCID: https://orcid.org/0000-0002-1942-1222)
- G.A. Amos Burke (ORCID: https://orcid.org/0000-0003-2671-9972)
- Ruth Lydia Ladenstein (ORCID: https://orcid.org/0000-0001-6548-3873)
- Grace Holt (ORCID: https://orcid.org/0000-0002-1123-7471)
- Soledad Gallego (ORCID: https://orcid.org/0000-0002-4712-9624)
- Aurora Castellano (ORCID: https://orcid.org/0000-0002-2316-4927)
- Dominique Valteau‐Couanet (ORCID: https://orcid.org/0009-0001-9880-2241)
- C. Michel Zwaan (ORCID: https://orcid.org/0000-0001-6892-8268)
- Keith Wheatley (ORCID: https://orcid.org/0000-0003-0792-580X)
- Antony Ng
- Juliet C. Gray (ORCID: https://orcid.org/0000-0002-5652-4722)
- Adela Cañete (ORCID: https://orcid.org/0000-0002-5669-5097)
- Martin Elliott (ORCID: https://orcid.org/0000-0002-8062-6913)
- Charlotte Firth
- Guy Makin (ORCID: https://orcid.org/0000-0003-3513-3957)
- Nicolas U. Gerber (ORCID: https://orcid.org/0000-0002-1783-631X)
- Jennifer Laidler
- Estelle Thébaud (ORCID: https://orcid.org/0000-0003-0516-4103)
- Anne Sophie Defachelles (ORCID: https://orcid.org/0000-0002-4277-9871)
- Lisa Howell (ORCID: https://orcid.org/0000-0003-2119-2630)
- Marion Gambart (ORCID: https://orcid.org/0000-0002-4364-5170)
- Sucheta Vaidya (ORCID: https://orcid.org/0000-0003-2980-9316)
- Cormac Owens (ORCID: https://orcid.org/0000-0001-6559-3239)
- Andrew D.J. Pearson (ORCID: https://orcid.org/0000-0002-8738-5913)
- Deborah A. Tweddle (ORCID: https://orcid.org/0000-0003-2208-3970)
- Pamela R. Kearns (ORCID: https://orcid.org/0000-0003-2756-5813)
- Sally L. George (ORCID: https://orcid.org/0000-0003-2777-4922)
- Bénédicte Brichard (ORCID: https://orcid.org/0000-0003-2765-1711)
- Bram De Wilde (ORCID: https://orcid.org/0000-0003-0213-1322)
- Anthony McCarthy (ORCID: https://orcid.org/0000-0003-3420-5605)
- Natasha K. A. van Eijkelenburg (ORCID: https://orcid.org/0000-0002-0526-3737)
- Louis Chesler (ORCID: https://orcid.org/0000-0001-7842-2068)
- Rebekah Weston (ORCID: https://orcid.org/0000-0002-7884-1884)
- Sarah Jannier (ORCID: https://orcid.org/0000-0002-6646-2473)
- Ricardo López Almaraz (ORCID: https://orcid.org/0000-0001-5521-9892)
- Alba Rubio‐San‐Simón (ORCID: https://orcid.org/0000-0001-6426-7423)
- Lynley V. Marshall (ORCID: https://orcid.org/0000-0002-6537-2118)
- Karsten Nysom (ORCID: https://orcid.org/0000-0003-2935-0058)
- Gudrun Schleiermacher
- Giuseppe Barone (ORCID: https://orcid.org/0000-0003-3264-1913)
- Simon Gates (ORCID: https://orcid.org/0000-0003-3193-0975)
- Lucas Moreno (ORCID: https://orcid.org/0000-0002-0708-1670)
- V. V. Moroz
- Dermot Murphy
- Dan Yeomanson
Institutions
- Leeds General Infirmary (GB)
- Cliniques Universitaires Saint-Luc (BE)
- Institute of Cancer Research (GB)
- University of Liverpool (GB)
- Great Ormond Street Hospital (GB)
- Royal Victoria Infirmary (GB)
- Al Jalila Foundation (AE)
- Royal Belfast Hospital for Sick Children (GB)
- Institut Gustave Roussy (FR)
- Bristol Royal Hospital for Children (GB)
- Copenhagen University Hospital (DK)
- Rigshospitalet (DK)
- Centre Hospitalier Universitaire de Nantes (FR)
- BioCruces Health research Institute (ES)
- Birmingham Women's Hospital (GB)
- Hôpital d'Enfants (FR)
- Centre Léon Bérard (FR)
- Hospital Infantil Universitario Niño Jesús (ES)
- Royal Marsden Hospital (GB)
- Bambino Gesù Children's Hospital (IT)
- St Anna Children's Hospital (AT)
- Universitair Ziekenhuis Brussel (BE)
- Princess Máxima Center (NL)
- Vall d'Hebron Hospital Universitari (ES)
- University Children's Hospital Zurich (CH)
- Centre Oscar Lambret (FR)
- Cancer Research UK Clinical Trials Unit (GB)
- Our Lady's Hospital (IE)
- Erasmus MC - Sophia Children’s Hospital (NL)
- Hôpital des Enfants (FR)
- Hôpital d'Hautepierre (FR)
- Alder Hey Children's Hospital (GB)
- Royal Manchester Children's Hospital (GB)
- NIHR Birmingham Biomedical Research Centre (GB)
- Sheffield Children's Hospital (GB)
- Instituto de Investigación Sanitaria La Fe (ES)
- University of Southampton (GB)
- University College London (GB)
- University of Birmingham (GB)
- Institut Curie (FR)
Publication Details
- Journal
- Journal of Clinical Oncology
- Published
- 2025-12-12
- DOI
- https://doi.org/10.1200/jco-25-01868
- Citations
- 1
- Primary Topic
- Neuroblastoma Research and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 1.39
Funders
- Solving Kids' Cancer
- Cancer Research UK
- EUSA Pharma