Synergistic innate-adaptive immunity by NKG2D-specific CAR-macrophages drives durable remission in hepatocellular carcinoma
NKG2D-directed CAR-Ms eliminate HCC through integrated innate phagocytosis, adaptive immune activation, and myeloid reprogramming, overcoming key therapeutic barriers. Combination with anti-PD-L1 enhances therapeutic efficacy by leveraging innate-adaptive crosstalk, providing a promising approach for HCC immunotherapy.
Authors
- Haohan Lyu
- Wenjie Song
- Feng Chang
- Junwei Jiang
- Chen Liu (ORCID: https://orcid.org/0000-0002-7797-3869)
- Chen Zhang (ORCID: https://orcid.org/0000-0001-6571-6446)
- Lingling Zhang (ORCID: https://orcid.org/0000-0002-6272-7171)
- Han Zhang (ORCID: https://orcid.org/0000-0002-0166-1973)
- Tao Wang (ORCID: https://orcid.org/0000-0001-6402-5571)
- Yang He (ORCID: https://orcid.org/0000-0001-5514-2370)
- Zihao Zhao (ORCID: https://orcid.org/0000-0001-7497-3276)
- Wenjing Zheng (ORCID: https://orcid.org/0000-0002-6584-1359)
- Weiwei Qin (ORCID: https://orcid.org/0000-0002-2872-257X)
- Yi Huo (ORCID: https://orcid.org/0000-0003-2144-4033)
- Lequn Shan (ORCID: https://orcid.org/0000-0002-6490-5437)
Institutions
- Xi'an Honghui Hospital (CN)
- Xijing Hospital (CN)
- Xi'an Jiaotong University (CN)
- Air Force Medical University (CN)
Publication Details
- Journal
- Molecular Cancer
- Published
- 2025-12-13
- DOI
- https://doi.org/10.1186/s12943-025-02538-w
- Citations
- 2
- Primary Topic
- Immune Cell Function and Interaction
- Type
- article
- Field-Weighted Citation Impact
- 1.59