Healthcare Utilization, Costs, and Cost-Effectiveness of Patients Undergoing Laparoscopic and Open Hemihepatectomy: A Secondary Analysis of the ORANGE II PLUS Randomized Controlled, Phase 3, Superiority Trial
Although LH was more costly than OH, in a multicenter randomized trial, its clinical advantages translated into more QALYs gained over the first postoperative year and high probability of cost-effectiveness. These findings suggest that, where resources allow, LH may be preferred over OH for selected patients, offering both clinical benefits and acceptable economic value.
Authors
- Krishna Menon (ORCID: https://orcid.org/0000-0002-8193-4889)
- Aude Vanlander (ORCID: https://orcid.org/0000-0002-4457-4255)
- John Primrose (ORCID: https://orcid.org/0000-0002-2069-7605)
- Marc G. Besselink (ORCID: https://orcid.org/0000-0003-2650-9350)
- Valério Lucidi (ORCID: https://orcid.org/0000-0001-7347-9727)
- Steven White (ORCID: https://orcid.org/0000-0002-6519-9853)
- Robert S. Fichtinger (ORCID: https://orcid.org/0000-0002-9143-8213)
- Mariëlle M.E. Coolsen (ORCID: https://orcid.org/0000-0002-1608-6668)
- Rafael Díaz-Nieto
- Somaiah Aroori (ORCID: https://orcid.org/0000-0002-5613-6463)
- Francesca Ratti (ORCID: https://orcid.org/0000-0002-8108-9064)
- Lloyd Brandts (ORCID: https://orcid.org/0000-0002-0620-1271)
- Bram Olij (ORCID: https://orcid.org/0000-0002-1027-8685)
- Ronald M. van Dam (ORCID: https://orcid.org/0000-0001-8415-5090)
- Zina Eminton (ORCID: https://orcid.org/0009-0001-2747-4279)
- Gabriela Pilz da Cunha (ORCID: https://orcid.org/0000-0001-9055-1049)
- Vincenzo Scuderi (ORCID: https://orcid.org/0000-0002-0490-7780)
- Merel Kimman (ORCID: https://orcid.org/0000-0002-5717-5704)
- Gregory Sergeant (ORCID: https://orcid.org/0000-0001-8846-3824)
- Maxime Dewulf (ORCID: https://orcid.org/0000-0002-1945-5481)
- T.F. Ulmer (ORCID: https://orcid.org/0000-0003-0602-7207)
- Pieter J. Tanis (ORCID: https://orcid.org/0000-0002-3146-3310)
- S. Pugh (ORCID: https://orcid.org/0000-0002-1866-8338)
- Åsmund Avdem Fretland (ORCID: https://orcid.org/0000-0002-0945-5189)
- R. Sutcliffe
- Ulf P. Neumann (ORCID: https://orcid.org/0000-0002-3831-8917)
- Zahir Soonawalla (ORCID: https://orcid.org/0000-0002-4213-4723)
- Bjørn Edwin (ORCID: https://orcid.org/0000-0002-3137-6225)
- Ravi Marudanayagam (ORCID: https://orcid.org/0000-0002-0640-3535)
- Mathieu D’Hondt
- Frederik Berrevoet
- Christoph Kuemmerli
- Roberto Troisi
- Mohammad Abu Hilal
Institutions
- University of Jordan (JO)
- Oslo University Hospital (NO)
- University Hospitals Birmingham NHS Foundation Trust (GB)
- University of Liverpool (GB)
- Vita-Salute San Raffaele University (IT)
- Aintree University Hospitals NHS Foundation Trust (GB)
- Maastricht University Medical Centre (NL)
- AZ Groeninge (BE)
- Ghent University Hospital (BE)
- Newcastle upon Tyne Hospitals NHS Foundation Trust (GB)
- Erasmus Hospital (BE)
- Maastricht University (NL)
- Jessa Hospital (BE)
- King's College Hospital NHS Foundation Trust (GB)
- Federico II University Hospital (IT)
- NIHR Southampton Biomedical Research Centre (GB)
- Essen University Hospital (DE)
- Oxford University Hospitals NHS Trust (GB)
- Amsterdam University Medical Centers (NL)
- Istituti di Ricovero e Cura a Carattere Scientifico (IT)
- Addenbrooke's Hospital (GB)
- Plymouth Hospital (GB)
- University Hospitals Plymouth NHS Trust (GB)
- University of Southampton (GB)
- Istituto di Ricovero e Cura a Carattere Scientifico San Raffaele (IT)
- Hasselt University (BE)
- University of Amsterdam (NL)
- RWTH Aachen University (DE)
Publication Details
- Journal
- Annals of Surgical Oncology
- Published
- 2025-12-12
- DOI
- https://doi.org/10.1245/s10434-025-18779-4
- Citations
- 2
- Primary Topic
- Hepatocellular Carcinoma Treatment and Prognosis
- Type
- article
- Field-Weighted Citation Impact
- 2.64