Enzyme-like Hydrogen Atom Transfer (HAT) Based Endo-Functionalized Molecular Receptors
We report a series of endo-functionalized molecular receptors based on a calix[4]pyrrole scaffold, which exhibit Hydrogen Atom Transfer (HAT) reactivity towards free-radicals (e.g., peroxyl radicals). The chemical structure and shape of the molecular receptors affect the affinity towards free-radicals, while host-guest interactions are used to fine-tune the HAT reactivity, mimicking enzyme modulation in biological systems.
Authors
- Luca Valgimigli (ORCID: https://orcid.org/0000-0003-2229-1075)
- Pablo Ballester (ORCID: https://orcid.org/0000-0001-8377-6610)
- Manuel Petroselli (ORCID: https://orcid.org/0000-0002-4388-9386)
- Corrado Bacchiocchi (ORCID: https://orcid.org/0000-0002-8676-0558)
- Wenkai Pan (ORCID: https://orcid.org/0009-0000-7541-1291)
- Anastasia Grigoryeva
Institutions
- Università di Camerino (IT)
- Institució Catalana de Recerca i Estudis Avançats (ES)
- Università degli Studi del Piemonte Orientale “Amedeo Avogadro” (IT)
- Institut Català d'Investigació Química (ES)
- Ospedale Infermi di Rimini (IT)
- University of Bologna (IT)
Publication Details
- Journal
- Organic Letters
- Published
- 2025-12-12
- DOI
- https://doi.org/10.1021/acs.orglett.5c04339
- Primary Topic
- Molecular Sensors and Ion Detection
- Type
- article
- Field-Weighted Citation Impact
- 0.00