Low dose IFNγ remodels enhancer landscape to potentiate mesenchymal stromal cell activation
This study demonstrates that low dose IFNγ is sufficient to modulate the transcriptional and epigenetic landscape of MSCs by selectively altering enhancer landscape. Our results provide insights into the regulatory mechanisms underlying IFNγ priming and offer a resource for the rational design of strategies to optimize MSC licensing for therapeutic applications.
Authors
- Xuan Cao (ORCID: https://orcid.org/0000-0001-9713-4192)
- Hu Q (ORCID: https://orcid.org/0000-0002-1718-4542)
- Siwang Hu (ORCID: https://orcid.org/0000-0002-8685-1441)
- Junxin Lin (ORCID: https://orcid.org/0000-0003-1838-026X)
- Dengfeng Ruan (ORCID: https://orcid.org/0000-0003-3390-4260)
- Wenyan Zhou (ORCID: https://orcid.org/0009-0002-1524-3067)
Institutions
- Taizhou First People's Hospital (CN)
- The First People's Hospital of Wenling (CN)
- Second Affiliated Hospital of Zhejiang University (CN)
- Taizhou University (CN)
Publication Details
- Journal
- Stem Cell Research & Therapy
- Published
- 2025-12-12
- DOI
- https://doi.org/10.1186/s13287-025-04801-9
- Primary Topic
- Mesenchymal stem cell research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Zhejiang Province