Release of Airway Alarmins <scp>IL</scp> ‐33 and <scp>TSLP</scp> in Paediatric Acute Severe Asthma: A Case–Control Study
IL-33 and TSLP were significantly elevated during acute severe asthma attacks and could potentially drive further airway inflammation and remodelling during asthma attacks in children. Results support further clinical evaluation of anti-TSLP and anti-IL-33 biologic therapeutics for preventing or reducing the frequency of asthma attacks in children.
Authors
- H Killick
- Manisha Ramphul (ORCID: https://orcid.org/0000-0002-6209-3869)
- Kathryn G. Welsh
- Christopher Edward Brightling (ORCID: https://orcid.org/0000-0002-9345-4903)
- Erol Gaillard (ORCID: https://orcid.org/0000-0003-0996-8133)
- Will Monteiro
- Ian C. Scott (ORCID: https://orcid.org/0000-0003-4136-4751)
Institutions
- University of Leicester (GB)
- Leicester Royal Infirmary (GB)
- AstraZeneca (Finland) (FI)
- NIHR Leicester Biomedical Research Centre (GB)
Publication Details
- Journal
- Acta Paediatrica
- Published
- 2025-12-12
- DOI
- https://doi.org/10.1111/apa.70416
- Primary Topic
- IL-33, ST2, and ILC Pathways
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- AstraZeneca
- Asthma and Lung UK