Association Between Smoking and Opioid Requirement and Pain Intensity in the Early Postoperative Period: A Meta-Analysis
Despite low-quality evidence due to non-randomized study designs, this meta-analysis demonstrates that patients who smoke have significantly higher postoperative opioid requirements and pain scores than nonsmokers. These findings highlight the need to consider smoking status when developing postoperative pain management strategies. Further research is needed to elucidate the mechanisms underlying this relationship and optimize pain control in smokers.
Authors
- Christoph Klivinyi (ORCID: https://orcid.org/0000-0003-0539-2704)
- Connor T. A. Brenna (ORCID: https://orcid.org/0000-0002-6126-3897)
- Istvan-Szilard Szilagyi (ORCID: https://orcid.org/0000-0001-7542-3911)
- Brigitte Messerer (ORCID: https://orcid.org/0000-0001-5343-8629)
- Kordula Lang-Illievich (ORCID: https://orcid.org/0000-0003-2648-2485)
- Torsten Ullrich (ORCID: https://orcid.org/0000-0002-7866-9762)
- Helmar Bornemann‐Cimenti (ORCID: https://orcid.org/0000-0002-1201-3752)
Institutions
- University of Toronto (CA)
- Medical University of Graz (AT)
- Graz University of Technology (AT)
- Klinikum Ingolstadt (DE)
- Fraunhofer Austria (AT)
Publication Details
- Journal
- Pain and Therapy
- Published
- 2025-12-13
- DOI
- https://doi.org/10.1007/s40122-025-00804-9
- Citations
- 1
- Primary Topic
- Opioid Use Disorder Treatment
- Type
- article
- Field-Weighted Citation Impact
- 1.88