UTX/Top2β axis mediated spinal cord microvascular endothelial cells senescence exacerbates spinal cord injury
UTX deletion attenuates vascular endothelial senescence and promotes angiogenesis after SCI by upregulating Top2β expression. This newly defined UTX/Top2β axis regulates vascular regeneration and represents a potential therapeutic target for promoting vascular repair following SCI.
Authors
- Jianzhong Hu (ORCID: https://orcid.org/0000-0001-8546-5111)
- Yudong Liu (ORCID: https://orcid.org/0000-0002-5153-3400)
- Tianding Wu
- Dongliang Liu (ORCID: https://orcid.org/0009-0003-3857-4763)
Institutions
- Central South University (CN)
- Hunan Cancer Hospital (CN)
- Xiangya Hospital Central South University (CN)
Publication Details
- Journal
- PLoS ONE
- Published
- 2025-12-12
- DOI
- https://doi.org/10.1371/journal.pone.0338326
- Primary Topic
- Angiogenesis and VEGF in Cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.00