High‐Protein Diet Exacerbates Insulin Resistance via the <scp>JNK</scp> / <scp>IKKβ</scp> ‐ <scp>IRS</scp> ‐1 Pathway
A HP diet induces insulin resistance in normal mice and further exacerbates glucose metabolism disorders in T2D models, suggesting that restricting HP intake may serve as a strategy for preventing T2D.
Authors
- Yuchen Jiang (ORCID: https://orcid.org/0000-0003-4660-7847)
- Simin Chen (ORCID: https://orcid.org/0009-0006-2807-0109)
- Yuxin Yang (ORCID: https://orcid.org/0000-0002-1742-2328)
- Jinmiao Tian (ORCID: https://orcid.org/0009-0000-5056-0151)
- Lili Zhao (ORCID: https://orcid.org/0000-0002-6366-8206)
- B Wang
- Junjun Li (ORCID: https://orcid.org/0000-0003-4351-5496)
- Lei Yan (ORCID: https://orcid.org/0000-0001-7075-0438)
- Jing Wang (ORCID: https://orcid.org/0000-0003-2294-9981)
- Lulu Wang (ORCID: https://orcid.org/0000-0002-5301-6669)
- Lixia Chen (ORCID: https://orcid.org/0000-0003-2196-1428)
- Jinhua Xu (ORCID: https://orcid.org/0000-0001-9104-1294)
- Yongming Yang (ORCID: https://orcid.org/0000-0002-8816-2500)
- Xihua Yang
Institutions
- Shanxi Medical University (CN)
- Shanxi Provincial Cancer Hospital (CN)
Publication Details
- Journal
- Endocrinology Diabetes & Metabolism
- Published
- 2025-12-12
- DOI
- https://doi.org/10.1002/edm2.70147
- Primary Topic
- NF-κB Signaling Pathways
- Type
- article
- Field-Weighted Citation Impact
- 0.00