(±)-Rutacycoumarins A and B: two pairs of unprecedented coumarin enantiomers from the aerial part of <i>Ruta graveolens</i> L. and chemically synthesized
This study isolated two novel benzofuran enantiomer pairs with fused cyclopropane motifs from <i>R. graveolens</i> Their structures were confirmed <i>via</i> a new catalytic EDA complex synthesis. Racemic mixtures reduced LPS-induced liver/cellular damage and cytokines in HepG2 cells, while all enantiomers inhibited MAO-B.
Authors
- Hao Huang (ORCID: https://orcid.org/0000-0002-5570-6145)
- Tao Jiang (ORCID: https://orcid.org/0000-0002-9854-7228)
- Yueping Jiang (ORCID: https://orcid.org/0000-0002-5820-0123)
- Yanyang Liu (ORCID: https://orcid.org/0000-0002-6270-0948)
- Feng Xu (ORCID: https://orcid.org/0000-0001-9985-6527)
- Chengyu Ge
- Jing Fang (ORCID: https://orcid.org/0000-0003-3071-5771)
- Shao Liu (ORCID: https://orcid.org/0000-0002-0576-8698)
- Xiongjun Hou
- Xiaolin Liao
- Aimin Wang (ORCID: https://orcid.org/0000-0001-7802-4908)
Institutions
- Jiangxi University of Traditional Chinese Medicine (CN)
- Central South University (CN)
- Hunan University (CN)
- First Affiliated Hospital of Jiangxi Medical College (CN)
- Hunan Mawangdui Hospital (CN)
- Gannan Medical University (CN)
- National Clinical Research (US)
- International Drug Development (FR)
- Xiangya Hospital Central South University (CN)
Publication Details
- Journal
- Pharmaceutical Biology
- Published
- 2025-12-13
- DOI
- https://doi.org/10.1080/13880209.2025.2600291
- Primary Topic
- Plant chemical constituents analysis
- Type
- article
- Field-Weighted Citation Impact
- 0.00