<i>APOE, ABCA7</i> , and <i>RASGEF1C</i> are associated with earlier onset of amyloid deposition from more than 4000 harmonized positron emission tomography images
Novel methods estimate how long ago a patient converted to amyloid positivity. Estimating this amyloid clock allows us to determine the onset of the earliest Alzheimer's disease changes. We evaluated what genes influence when someone converts to amyloid positivity. Apolipoprotein E (APOE), ABCA7, and RASGEF1C associated with earlier age of amyloid positivity. Genetic results were supported by tissue-specific expression analyses.
Authors
- Reisa Anne Sperling (ORCID: https://orcid.org/0000-0003-1535-6133)
- Tonnar Castellano (ORCID: https://orcid.org/0009-0008-9480-5497)
- Susan M. Resnick (ORCID: https://orcid.org/0000-0003-1115-7145)
- Duygu Tosun (ORCID: https://orcid.org/0000-0001-8644-7724)
- Timothy J. Hohman (ORCID: https://orcid.org/0000-0002-3377-7014)
- Tobey J. Betthauser (ORCID: https://orcid.org/0000-0001-8856-1352)
- Vilas Menon (ORCID: https://orcid.org/0000-0002-4096-8601)
- David Alan Bennett (ORCID: https://orcid.org/0000-0003-3689-554X)
- Julie A. Schneider (ORCID: https://orcid.org/0000-0002-9482-1752)
- Marilyn Albert (ORCID: https://orcid.org/0000-0002-8167-8985)
- Andrew J. Saykin (ORCID: https://orcid.org/0000-0002-1376-8532)
- Derek B. Archer (ORCID: https://orcid.org/0000-0001-8638-0785)
- Logan C. Dumitrescu (ORCID: https://orcid.org/0000-0002-9782-9944)
- Mary Ellen I. Koran (ORCID: https://orcid.org/0000-0002-3322-9114)
- Karly Alex Cody (ORCID: https://orcid.org/0000-0001-5996-2560)
- Michelle Clifton
- Corinne D. Engelman (ORCID: https://orcid.org/0000-0003-4750-5607)
- Philip L. De Jager (ORCID: https://orcid.org/0000-0002-8057-2505)
- Yiyang Wu (ORCID: https://orcid.org/0000-0002-9231-7093)
- Emma Nolan (ORCID: https://orcid.org/0009-0004-9692-0297)
- Elizabeth C. Mormino (ORCID: https://orcid.org/0000-0002-4542-6537)
- Theresa M. Harrison (ORCID: https://orcid.org/0000-0002-2036-3496)
- Mengna Zhang
- Sterling C. Johnson (ORCID: https://orcid.org/0000-0002-8501-545X)
- Murat Bilgel (ORCID: https://orcid.org/0000-0001-5042-7422)
- Badri Narayan Vardarajan (ORCID: https://orcid.org/0000-0002-5560-4085)
- Alaina Durant
- Tianyu Wang (ORCID: https://orcid.org/0000-0002-7747-2685)
- Vaibhav A. Janve
- William Jagust
- Richard Mayeux
- Alexis Regelson
Institutions
- Brigham and Women's Hospital (US)
- Rush University Medical Center (US)
- National Institutes of Health (US)
- NewYork–Presbyterian Hospital (US)
- University of Wisconsin–Madison (US)
- Johns Hopkins University (US)
- University of California, San Francisco (US)
- Columbia University Irving Medical Center (US)
- Johns Hopkins Medicine (US)
- University of California System (US)
- Massachusetts General Hospital (US)
- Mayo Clinic in Arizona (US)
- University of Wisconsin Health (US)
- Institute on Aging (US)
- National Institute on Aging (US)
- Wisconsin Division of Public Health (US)
- New York Genome Center (US)
- Indiana University – Purdue University Indianapolis (US)
- Vanderbilt University Medical Center (US)
- University of California, Berkeley (US)
- Stanford University (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz.71006
- Primary Topic
- Alzheimer's disease research and treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Alzheimer's Association
- National Institutes of Health
- National Institute on Aging