Identification of a chromatin-modifying gene-histone lysine N-methyl transferase (KMT2C/MLL3) as a potential immunomodulator oncogene in Indian pancreatic cancer patients
This study suggests KMT2C to be a putative oncogene in Indian PanCa patients in contrast with Western PanCa patients, with immunomodulatory effects and therapeutic potential, implicating its role as a promising biomarker, requiring additional clinical validation, emphasizing the necessity of ethnically informed precision oncology.
Authors
- Shuchismita Chakraborty (ORCID: https://orcid.org/0000-0001-6420-9557)
- Shouvik Choudhury (ORCID: https://orcid.org/0000-0003-2913-1955)
- Arnab Pal (ORCID: https://orcid.org/0000-0002-0850-3118)
- Debabrata Ghosh Dastidar (ORCID: https://orcid.org/0000-0002-4762-7295)
- Akash Bararia
- Sudeep Banerjee (ORCID: https://orcid.org/0000-0002-0522-3479)
- Sumit Mukherjee (ORCID: https://orcid.org/0000-0001-9807-7994)
- Sayan Saha (ORCID: https://orcid.org/0000-0002-9028-3600)
- Nilabja Sikdar (ORCID: https://orcid.org/0000-0003-4465-472X)
- Supriyo Ghatak (ORCID: https://orcid.org/0000-0003-0486-7800)
- Bitan Kumar Chattopadhay
- Shibajyoti Ghosh
- Arunima Maiti
Institutions
- Ben-Gurion University of the Negev (IL)
- Apollo Hospitals (IN)
- Tata Medical Center (IN)
- Liver Foundation West Bengal (IN)
- Span Diagnostics (India) (IN)
- Shanghai Estuarine & Coastal Science Research Center (CN)
- Biomedical Research Foundation (BD)
- Indian Statistical Institute (IN)
- Medical College and Hospital, Kolkata (IN)
Publication Details
- Journal
- European journal of medical research
- Published
- 2025-12-14
- DOI
- https://doi.org/10.1186/s40001-025-03661-6
- Primary Topic
- Epigenetics and DNA Methylation
- Type
- article
- Field-Weighted Citation Impact
- 0.00