Targeting the p53 pathway to treat atypical teratoid rhabdoid tumors

Combining MDM2 inhibitors and XPO1 inhibitors is a promising therapeutic strategy for treating children with ATRT.

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Publication Details

Journal
Neuro-Oncology Pediatrics
Published
2025-12-13
DOI
https://doi.org/10.1093/neuped/wuaf018
Primary Topic
Chromatin Remodeling and Cancer
Type
article
Field-Weighted Citation Impact
0.00
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article

Targeting the p53 pathway to treat atypical teratoid rhabdoid tumors

Michele Connelly, Sarah Robinson, Martine F. Roussel, Hyekyung P. Cho et al.
Neuro-Oncology Pediatrics
Chromatin Remodeling and Cancer
article

Targeting the p53 pathway to treat atypical teratoid rhabdoid tumors

Michele Connelly, Sarah Robinson, Martine F. Roussel, Hyekyung P. Cho, Alaa Refaat, Rebekah DeVries, Kimberly Mercer, Ayush Attery, Clinton F. Stewart, Burgess B. Freeman, Debolina Ganguly, Christopher L. Tinkle, Elizabeth A. Stewart, Kaiwen Yu, Nathaniel Twarog, Justin Williams, Sandeep Kumar Dhanda, Charles W.M. Roberts, Anang A. Shelat, Jennifer L. Stripay, Santhosh A. Upadhyaya, Evan Savage, Dipranjan Laha, Suresh Poudel, Kaley Blankenship
article en

Abstract

Combining MDM2 inhibitors and XPO1 inhibitors is a promising therapeutic strategy for treating children with ATRT.

Neuro-Oncology PediatricsVol. 2(1)
St. Jude Children's Research Hospital (US), Abterra Biosciences (United States) (US), Culture Resource (EG), Pharmaceutical Biotechnology (Czechia) (CZ)
Openalex Percentile: Top 63%
Chromatin Remodeling and Cancer
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Targeting the p53 pathway to treat atypical teratoid rhabdoid tumors — Michele Connelly, Sarah Robinson, et al. · Neuro-Oncology Pediatrics (2025) | TGRS Research Map | TGRS