Targeting the p53 pathway to treat atypical teratoid rhabdoid tumors
Combining MDM2 inhibitors and XPO1 inhibitors is a promising therapeutic strategy for treating children with ATRT.
Authors
- Michele Connelly
- Sarah Robinson (ORCID: https://orcid.org/0000-0002-5323-5124)
- Martine F. Roussel (ORCID: https://orcid.org/0000-0002-1740-8139)
- Hyekyung P. Cho (ORCID: https://orcid.org/0000-0001-5393-2600)
- Alaa Refaat
- Rebekah DeVries
- Kimberly Mercer
- Ayush Attery (ORCID: https://orcid.org/0009-0007-6996-5424)
- Clinton F. Stewart (ORCID: https://orcid.org/0000-0002-1546-9720)
- Burgess B. Freeman (ORCID: https://orcid.org/0000-0003-2174-5119)
- Debolina Ganguly (ORCID: https://orcid.org/0000-0002-7184-0053)
- Christopher L. Tinkle (ORCID: https://orcid.org/0000-0001-5552-2664)
- Elizabeth A. Stewart (ORCID: https://orcid.org/0000-0003-1110-2400)
- Kaiwen Yu (ORCID: https://orcid.org/0000-0002-6050-8477)
- Nathaniel Twarog (ORCID: https://orcid.org/0000-0003-1738-6387)
- Justin Williams (ORCID: https://orcid.org/0000-0002-0195-5509)
- Sandeep Kumar Dhanda (ORCID: https://orcid.org/0000-0003-1381-7434)
- Charles W.M. Roberts
- Anang A. Shelat (ORCID: https://orcid.org/0000-0002-6266-2910)
- Jennifer L. Stripay (ORCID: https://orcid.org/0000-0002-0039-8675)
- Santhosh A. Upadhyaya (ORCID: https://orcid.org/0000-0001-6101-149X)
- Evan Savage
- Dipranjan Laha (ORCID: https://orcid.org/0000-0002-3763-4395)
- Suresh Poudel (ORCID: https://orcid.org/0000-0002-8025-9607)
- Kaley Blankenship
Institutions
- St. Jude Children's Research Hospital (US)
- Abterra Biosciences (United States) (US)
- Culture Resource (EG)
- Pharmaceutical Biotechnology (Czechia) (CZ)
Publication Details
- Journal
- Neuro-Oncology Pediatrics
- Published
- 2025-12-13
- DOI
- https://doi.org/10.1093/neuped/wuaf018
- Primary Topic
- Chromatin Remodeling and Cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.00