Salience network dysfunction in SLE: convergent roles of complement activation and altered serotonergic signaling
Our study identifies a convergent mechanism in which complement-mediated inflammation, and serotonergic signalling alterations may collectively contribute to SN dysregulation in SLE. These findings provide new insights into potential biomarkers and therapeutic targets for SLE-related neural dysfunction.
Authors
- Ruiwang Huang (ORCID: https://orcid.org/0000-0003-3889-169X)
- Xiangliang Tan
- Xinrui Li (ORCID: https://orcid.org/0000-0001-7158-4785)
- Lin‐Hui Wang (ORCID: https://orcid.org/0000-0001-5295-324X)
- Qin Huang (ORCID: https://orcid.org/0000-0001-8971-3821)
- Xia Liu (ORCID: https://orcid.org/0000-0002-8759-1012)
- Liwei Tan
- Taihan Chen
Institutions
- Army Medical University (CN)
- South China Normal University (CN)
- Ministry of Education (RW)
- Daping Hospital (CN)
- Southern Medical University (CN)
Publication Details
- Journal
- Lara D. Veeken
- Published
- 2025-11-26
- DOI
- https://doi.org/10.1093/rheumatology/keaf628
- Primary Topic
- Complement system in diseases
- Type
- article
- Field-Weighted Citation Impact
- 0.00