Deoxyuridine as a surrogate marker of thymidylate synthase inhibition contributes to a multivariable model predicting 5-FU/LV response in metastatic colorectal cancer
The method used enables simultaneous analysis of multiple compounds within a tumor homogenate. Measuring dUr in homogenates before and after folate modulation, prior to initiation of FLV-based chemotherapy, could help predict tumor response and guide the choice between LV and ARF for optimal folate support.
Authors
- Yvonne Wettergren (ORCID: https://orcid.org/0000-0001-8660-7169)
- Bengt Gustavsson
- Göran Carlsson
- Elisabeth Odin (ORCID: https://orcid.org/0009-0006-7123-6418)
Institutions
- Sahlgrenska University Hospital (SE)
Publication Details
- Journal
- Cancer Treatment and Research Communications
- Published
- 2025-12-13
- DOI
- https://doi.org/10.1016/j.ctarc.2025.101076
- Primary Topic
- Colorectal Cancer Treatments and Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00