Divergent Synthesis of Highly Functional 3-Trifluoromethylated Dihydropyrroles and Pyrroles via 6π-Photocyclization
Presented herein is a solvent-directed selective synthesis of 3-trifluoromethylated dihydropyrroles and pyrroles based on the anaerobic or aerobic reaction of trifluoromethyl-substituted dienamines via 6π-photocyclization. The work provides a robust protocol for the effective functionalization of dienamine derivatives, leading to the concise and selective assembly of pyrrole-related scaffolds bearing a pharmaceutically privileged CF<sub>3</sub> unit. This novel strategy features a photocatalyst-free process, divergent synthesis, formal hydroalkenylation, excellent regioselectivity, wide functional group tolerance, and operational convenience.
Authors
- Zhengwang Chen (ORCID: https://orcid.org/0000-0002-6795-9625)
- Wei Guo (ORCID: https://orcid.org/0000-0002-4456-3927)
- Haiqing Luo (ORCID: https://orcid.org/0000-0003-2159-8403)
- Daohong Yu (ORCID: https://orcid.org/0000-0003-4840-9051)
- M. Li
- Wenjun Luo (ORCID: https://orcid.org/0000-0001-6760-6929)
- Jinbin Zhu (ORCID: https://orcid.org/0000-0002-7932-9962)
- Yuping Zhu
- Lipeng Long
Institutions
- Jiangnan University (CN)
- Gannan Normal University (CN)
Publication Details
- Journal
- Organic Letters
- Published
- 2025-12-13
- DOI
- https://doi.org/10.1021/acs.orglett.5c04662
- Primary Topic
- Fluorine in Organic Chemistry
- Type
- article
- Field-Weighted Citation Impact
- 0.00