CD177 <sup>+</sup> neutrophils drive extracellular matrix remodelling and HGF-alpha release in ALPPS-induced liver regeneration
CD177<sup>+</sup> neutrophils drive liver regeneration by promoting endothelial transmigration, ECM degradation and HGF-α release. These findings reveal a neutrophil-mediated mechanism driving surgical liver regeneration and support the potential of CD177<sup>+</sup> neutrophil infusion to establish a proregenerative hepatic environment for therapeutic strategies in liver failure.
Authors
- Miguel A. Esteban (ORCID: https://orcid.org/0000-0002-1426-6809)
- Zhen‐Bin Ding (ORCID: https://orcid.org/0000-0001-6613-8270)
- Na Yao (ORCID: https://orcid.org/0000-0002-8550-0519)
- Zhifeng Jiang (ORCID: https://orcid.org/0000-0001-5695-4522)
- Rong Gao (ORCID: https://orcid.org/0000-0002-8296-2224)
- Shao‐Lai Zhou (ORCID: https://orcid.org/0000-0002-8526-5221)
- Jia‐Yi Wang (ORCID: https://orcid.org/0000-0002-9106-3351)
- Rongkui Luo (ORCID: https://orcid.org/0000-0002-4118-7225)
- Junfeng Huang (ORCID: https://orcid.org/0000-0002-1672-3751)
- Zhao–You Tang (ORCID: https://orcid.org/0000-0002-9847-3150)
- Raymond Miao
- Ao Huang
- Jian‐Wen Cheng (ORCID: https://orcid.org/0000-0002-7571-0096)
- Xin‐Rong Yang (ORCID: https://orcid.org/0000-0002-2716-9338)
- Senquan Zhang
- Hans J. Schlitt (ORCID: https://orcid.org/0000-0002-3874-0296)
- Jiayan Yan (ORCID: https://orcid.org/0000-0003-1751-7842)
- Dongmei Gao (ORCID: https://orcid.org/0000-0003-3442-5704)
- Yuan Ji (ORCID: https://orcid.org/0000-0001-7063-2546)
- Zheng Wang (ORCID: https://orcid.org/0000-0002-8291-2825)
- Tianyi Li (ORCID: https://orcid.org/0000-0002-7746-1441)
- Feiyu Chen (ORCID: https://orcid.org/0000-0001-8677-7416)
- Jia Fan (ORCID: https://orcid.org/0000-0001-5158-629X)
- Jian Zhou (ORCID: https://orcid.org/0000-0002-2118-1117)
- Shiyu Zhang (ORCID: https://orcid.org/0000-0001-9021-3875)
- Qichao Yu (ORCID: https://orcid.org/0000-0003-2158-8424)
Institutions
- BGI Group (China) (CN)
- Ministry of Education of the People's Republic of China (CN)
- Shanghai Medical College of Fudan University (CN)
- Sun Yat-sen University (CN)
- Fudan University (CN)
- Southern University of Science and Technology (CN)
- Fahd bin Sultan University (SA)
- Zhongshan Hospital (CN)
- The First Affiliated Hospital, Sun Yat-sen University (CN)
- Shenzhen Third People’s Hospital (CN)
- University of Regensburg (DE)
Publication Details
- Journal
- Gut
- Published
- 2025-12-13
- DOI
- https://doi.org/10.1136/gutjnl-2025-336300
- Citations
- 2
- Primary Topic
- Liver physiology and pathology
- Type
- article
- Field-Weighted Citation Impact
- 2.64