Beyond COVID-19 in people with HIV: Specific miRNA expression profile persist after SARS-CoV-2 clearance
SARS-CoV-2 infection in PWHIV leaves an epigenetic signature of 35 SDE microRNAs, with hsa-miR-374b-5p as a strong post-infection marker. These microRNAs regulate genes mainly involved in neurodegenerative, cardiovascular, and oncologic processes, potentially underlying post-COVID symptomatology.
Authors
- Salvador Resino (ORCID: https://orcid.org/0000-0001-8783-0450)
- Rafael Micán (ORCID: https://orcid.org/0000-0002-6626-4266)
- Ignacio de los Santos (ORCID: https://orcid.org/0000-0001-7073-5211)
- Verónica Briz (ORCID: https://orcid.org/0000-0003-2297-5098)
- Juan Berenguer (ORCID: https://orcid.org/0000-0001-8541-8200)
- Violeta Lara‐Aguilar (ORCID: https://orcid.org/0000-0003-0015-5961)
- Sonia Arca-Lafuente (ORCID: https://orcid.org/0000-0003-4750-0988)
- Celia Crespo‐Bermejo (ORCID: https://orcid.org/0000-0002-2813-2481)
- Luz Martı́n-Carbonero (ORCID: https://orcid.org/0000-0001-8102-4079)
- Manuel Llamas‐Adán
- María Lagarde (ORCID: https://orcid.org/0000-0002-7712-6977)
- Sergio Grande‐García
- Santiago Moreno (ORCID: https://orcid.org/0000-0002-2843-1094)
- Amanda Fernández-Rodríguez
- Pablo Ryan (ORCID: https://orcid.org/0000-0002-4212-7419)
Institutions
- Instituto de Salud Carlos III (ES)
- Hospital General Universitario Gregorio Marañón (ES)
- Research Institute Hospital 12 de Octubre (ES)
- Hospital Universitario 12 De Octubre (ES)
- Centro Nacional de Microbiologia (ES)
- Hospital La Paz Institute for Health Research (ES)
- Centro de Investigación Biomédica en Red (ES)
- Instituto Ramón y Cajal de Investigación Sanitaria (ES)
- Hospital Universitario Infanta Leonor (ES)
Publication Details
- Journal
- Journal of Infection and Public Health
- Published
- 2025-12-13
- DOI
- https://doi.org/10.1016/j.jiph.2025.103108
- Primary Topic
- Long-Term Effects of COVID-19
- Type
- article
- Field-Weighted Citation Impact
- 0.00