Artificial intelligence-guided personalized ablation improves freedom from atrial arrhythmia in heart failure: A sub-analysis of the TAILORED-AF trial

Atrial fibrillation (AF) and heart failure (HF) frequently coexist, creating a complex clinical scenario that amplifies morbidity and worsens prognosis. Catheter ablation emerged as a cornerstone therapy for rhythm control in this population, particularly in patients with reduced ejection fraction1. However, the optimal ablation strategy remains debated, especially in those with advanced HF symptoms. This research letter presents a sub-analysis of the TAILORED-AF trial, which investigated the efficacy of a personalized, dispersion-guided ablation strategy targeting regions of spatiotemporal dispersion (tailored arm) compared to conventional anatomical pulmonary vein isolation (PVI, anatomical arm) in patients with persistent AF2.

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Publication Details

Journal
Heart Rhythm O2
Published
2025-12-13
DOI
https://doi.org/10.1016/j.hroo.2025.12.007
Primary Topic
Atrial Fibrillation Management and Outcomes
Type
article
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article

Artificial intelligence-guided personalized ablation improves freedom from atrial arrhythmia in heart failure: A sub-analysis of the TAILORED-AF trial

Isabel Deisenhofer, Dhanunjaya Lakkireddy, Seth Goldbarg, Sabine Lotteau et al.
Heart Rhythm O2
Atrial Fibrillation Management and Outcomes
article

Artificial intelligence-guided personalized ablation improves freedom from atrial arrhythmia in heart failure: A sub-analysis of the TAILORED-AF trial

Isabel Deisenhofer, Dhanunjaya Lakkireddy, Seth Goldbarg, Sabine Lotteau, Haroon Rashid, Julien Seitz, Paola Milpied, John D. Hummel, Stavros Mountantonakis, Jérôme Kalifa
article en

Abstract

Atrial fibrillation (AF) and heart failure (HF) frequently coexist, creating a complex clinical scenario that amplifies morbidity and worsens prognosis. Catheter ablation emerged as a cornerstone therapy for rhythm control in this population, particularly in patients with reduced ejection fraction1. However, the optimal ablation strategy remains debated, especially in those with advanced HF symptoms. This research letter presents a sub-analysis of the TAILORED-AF trial, which investigated the efficacy of a personalized, dispersion-guided ablation strategy targeting regions of spatiotemporal dispersion (tailored arm) compared to conventional anatomical pulmonary vein isolation (PVI, anatomical arm) in patients with persistent AF2.

Heart Rhythm O2Vol. 7(2)
Heart Rhythm Society (US), Northwell Health (US), New York Hospital Queens (US), The Ohio State University Wexner Medical Center (US), Bon Secours Heart & Vascular Institute (US), Hôpital Saint Joseph (FR), Deutsches Herzzentrum München (DE), Alaska Heart and Vascular Institute (US)
Openalex Percentile: Top 43%
Atrial Fibrillation Management and Outcomes
DOIOpen Access PDFOpenAlex
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Artificial intelligence-guided personalized ablation improves freedom from atrial arrhythmia in heart failure: A sub-analysis of the TAILORED-AF trial — Isabel Deisenhofer, Dhanunjaya Lakkireddy, et al. · Heart Rhythm O2 (2025) | TGRS Research Map | TGRS