Atherosclerosis licenses for an exceeding immune response in COVID-19 disease by interferon priming in circulating myeloid cells

This study demonstrates that patients with ASCVD show a dysregulated myeloid immune response in moderate COVID-19 disease. Mechanistically, epigenetic imprinting sensitizes myeloid cells of patients with ASCVD to an exaggerated type I interferon-associated immune response.

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Publication Details

Journal
Cardiovascular Research
Published
2025-12-12
DOI
https://doi.org/10.1093/cvr/cvaf268
Citations
1
Primary Topic
Immune cells in cancer
Type
article
Field-Weighted Citation Impact
0.80
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article

Atherosclerosis licenses for an exceeding immune response in COVID-19 disease by interferon priming in circulating myeloid cells

Christoph Römmele, Emmanouil G Solomonidis, Wesley Abplanalp, David John et al.
1 citations
Cardiovascular Research
Immune cells in cancer
0.80
article

Atherosclerosis licenses for an exceeding immune response in COVID-19 disease by interferon priming in circulating myeloid cells

Christoph Römmele, Emmanouil G Solomonidis, Wesley Abplanalp, David John, David M. Leistner, Julian Leberzammer, Chanil Valasarajan, Bianca Schuhmacher, Simone-Franziska Glaser, Maximilian Merten, Katharina Grikscheit, Christoph Stellbrink, Stefanie Dimmeler, Jörg Janne Vehreschild, Gabriele Anton, Vladimı́r Beneš, Annett Wilken‐Schmitz, Andreas M. Zeiher, Carsten Kuenne, Stefan Günther, Maria J. G. T. Vehreschild, Mario Looso, Sebastian Cremer, Ferris Jung, Sandra Ciesek, Siri Göpel, Soni Savai Pullamsetti, Vivianne Niehaus, Lara Korth, Gligorije Jeremijev
article en
1 citations

Abstract

This study demonstrates that patients with ASCVD show a dysregulated myeloid immune response in moderate COVID-19 disease. Mechanistically, epigenetic imprinting sensitizes myeloid cells of patients with ASCVD to an exaggerated type I interferon-associated immune response.

Cardiovascular ResearchVol. 122(1)
Goethe University Frankfurt (DE), Goethe-Institute United Kingdom (GB), Justus-Liebig-Universität Gießen (DE), Bielefeld University (DE), Hochschule Bielefeld (DE), Frankfurt Institute for Advanced Studies (DE), University Hospital Augsburg (DE), Max Planck Institute for Heart and Lung Research (DE), Fraunhofer Institute for Translational Medicine and Pharmacology (DE), German Center for Infection Research (DE), University Children's Hospital Tübingen (DE), German Centre for Cardiovascular Research (DE), Klinikum Bielefeld (DE), Universities of Giessen and Marburg Lung Center (DE), University Hospital Frankfurt (DE), Fraunhofer Institute for Molecular Biology and Applied Ecology (DE), European Molecular Biology Laboratory (DE), Cardio-Pulmonary Institute (DE), University of Tübingen (DE)
Openalex Percentile: Top 21%
Immune cells in cancer
0.80
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