Atherosclerosis licenses for an exceeding immune response in COVID-19 disease by interferon priming in circulating myeloid cells
This study demonstrates that patients with ASCVD show a dysregulated myeloid immune response in moderate COVID-19 disease. Mechanistically, epigenetic imprinting sensitizes myeloid cells of patients with ASCVD to an exaggerated type I interferon-associated immune response.
Authors
- Christoph Römmele (ORCID: https://orcid.org/0000-0002-8745-8510)
- Emmanouil G Solomonidis (ORCID: https://orcid.org/0000-0003-2536-4479)
- Wesley Abplanalp (ORCID: https://orcid.org/0000-0001-5996-8997)
- David John (ORCID: https://orcid.org/0000-0003-3217-5449)
- David M. Leistner (ORCID: https://orcid.org/0000-0002-4351-420X)
- Julian Leberzammer (ORCID: https://orcid.org/0000-0002-1717-0706)
- Chanil Valasarajan (ORCID: https://orcid.org/0000-0002-0969-9044)
- Bianca Schuhmacher
- Simone-Franziska Glaser (ORCID: https://orcid.org/0000-0002-0808-2659)
- Maximilian Merten (ORCID: https://orcid.org/0009-0001-4793-7146)
- Katharina Grikscheit (ORCID: https://orcid.org/0000-0003-1102-078X)
- Christoph Stellbrink (ORCID: https://orcid.org/0000-0002-8429-2826)
- Stefanie Dimmeler (ORCID: https://orcid.org/0000-0002-1045-2436)
- Jörg Janne Vehreschild (ORCID: https://orcid.org/0000-0002-5446-7170)
- Gabriele Anton (ORCID: https://orcid.org/0000-0003-0483-892X)
- Vladimı́r Beneš (ORCID: https://orcid.org/0000-0002-0352-2547)
- Annett Wilken‐Schmitz
- Andreas M. Zeiher (ORCID: https://orcid.org/0000-0003-1711-5819)
- Carsten Kuenne (ORCID: https://orcid.org/0000-0001-8013-5906)
- Stefan Günther (ORCID: https://orcid.org/0000-0002-5594-4549)
- Maria J. G. T. Vehreschild (ORCID: https://orcid.org/0000-0003-0446-3224)
- Mario Looso (ORCID: https://orcid.org/0000-0003-1495-9530)
- Sebastian Cremer (ORCID: https://orcid.org/0000-0002-6409-9279)
- Ferris Jung (ORCID: https://orcid.org/0000-0002-5534-7832)
- Sandra Ciesek
- Siri Göpel (ORCID: https://orcid.org/0000-0002-7666-4634)
- Soni Savai Pullamsetti
- Vivianne Niehaus
- Lara Korth
- Gligorije Jeremijev
Institutions
- Goethe University Frankfurt (DE)
- Goethe-Institute United Kingdom (GB)
- Justus-Liebig-Universität Gießen (DE)
- Bielefeld University (DE)
- Hochschule Bielefeld (DE)
- Frankfurt Institute for Advanced Studies (DE)
- University Hospital Augsburg (DE)
- Max Planck Institute for Heart and Lung Research (DE)
- Fraunhofer Institute for Translational Medicine and Pharmacology (DE)
- German Center for Infection Research (DE)
- University Children's Hospital Tübingen (DE)
- German Centre for Cardiovascular Research (DE)
- Klinikum Bielefeld (DE)
- Universities of Giessen and Marburg Lung Center (DE)
- University Hospital Frankfurt (DE)
- Fraunhofer Institute for Molecular Biology and Applied Ecology (DE)
- European Molecular Biology Laboratory (DE)
- Cardio-Pulmonary Institute (DE)
- University of Tübingen (DE)
Publication Details
- Journal
- Cardiovascular Research
- Published
- 2025-12-12
- DOI
- https://doi.org/10.1093/cvr/cvaf268
- Citations
- 1
- Primary Topic
- Immune cells in cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.80