HPDA-based tubule-targeting nanoplatform alleviates oxidative stress and ferroptosis for the reversal of renal interstitial fibrosis
In summary, Rosi@HPDA-PEG-K3 NPs deliver Rosi specifically to renal renal tubular epithelial cells(TECs)and exert an anti-RIF effect through the integration of ferroptosis inhibition, mitochondrial protection, and inflammation modulation. Our study establishes a nanotherapeutic platform with precise targeting and multifunctional efficacy, highlighting its scientific rigor and the clinical translational potential of RIF.
Authors
- Huifang Tan
- Peng Luo (ORCID: https://orcid.org/0000-0002-8215-2045)
- Yinyin Chen (ORCID: https://orcid.org/0009-0002-5034-404X)
- Ying Li (ORCID: https://orcid.org/0000-0002-5590-0765)
- Chen Zhou (ORCID: https://orcid.org/0000-0002-5513-3535)
- Guoli Li (ORCID: https://orcid.org/0000-0003-0450-2529)
- Dong Zeng (ORCID: https://orcid.org/0009-0003-5028-5534)
- Zheng Xiao (ORCID: https://orcid.org/0000-0003-2748-7042)
Institutions
- Central South University (CN)
- Hunan Normal University (CN)
- Hunan Provincial People's Hospital (CN)
- Colorado Kidney Care (US)
- Second Xiangya Hospital of Central South University (CN)
- Education Department of Hunan Province (CN)
Publication Details
- Journal
- Journal of Nanobiotechnology
- Published
- 2025-12-13
- DOI
- https://doi.org/10.1186/s12951-025-03927-5
- Citations
- 1
- Primary Topic
- Ferroptosis and cancer prognosis
- Type
- article
- Field-Weighted Citation Impact
- 1.52