Vitamin K2 Supplementation and Clinical Outcomes in Hepatocellular Carcinoma Patients: A Meta-Analysis with Trial Sequential Analysis
This study suggests substantial benefits associated with VK supplementation in HCC patients, particularly in reducing DR and mortality across one, two, and three years. Importantly, these improvements were achieved without a significant increase in adverse events, indicating good tolerability of VK supplementation in this population.
Authors
- Francisco Cézar Aquino de Moraes (ORCID: https://orcid.org/0000-0003-0623-8135)
- Jamile Cristine Marques Barros (ORCID: https://orcid.org/0000-0002-6891-0014)
- Rommel Mário Rodríguez Burbano (ORCID: https://orcid.org/0000-0002-4872-234X)
- Caroline R M Pereira (ORCID: https://orcid.org/0009-0001-4723-4563)
- Vitor Kendi Tsuchiya Sano (ORCID: https://orcid.org/0000-0001-8317-1857)
Institutions
- Universidade Federal do Acre (BR)
- Universidade de São Paulo (BR)
- Universidade do Porto (PT)
- Loyola Medicine (US)
- Universidade Federal do Pará (BR)
Publication Details
- Journal
- Nutrition and Cancer
- Published
- 2025-12-13
- DOI
- https://doi.org/10.1080/01635581.2025.2600102
- Primary Topic
- Vitamin K Research Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00