Biopsy-proven tyrosine kinase inhibitor–associated renal injury: a case series
TKI-induced renal injury characteristically presents with edema, hypertension and significant proteinuria, with renal-limited TMA as the predominant histopathological finding. Timely recognition and prompt discontinuation of the offending TKI, coupled with appropriate supportive nephroprotective management, generally yield favorable long-term renal outcomes with preservation of kidney function.
Authors
- Caihong Zeng (ORCID: https://orcid.org/0000-0002-3816-5164)
- Dacheng Chen (ORCID: https://orcid.org/0000-0002-6007-164X)
- Fan Yang (ORCID: https://orcid.org/0000-0003-0563-3395)
- Yongzhong Zhong (ORCID: https://orcid.org/0009-0007-7259-4644)
- Jing Tian (ORCID: https://orcid.org/0000-0002-9821-3295)
- Feng Xu (ORCID: https://orcid.org/0000-0002-1483-1425)
- Xiaodong Zhu
- J.‐D. Lian
- Shaoshan Liang
Institutions
- Nanjing General Hospital of Nanjing Military Command (CN)
- National Clinical Research (US)
- Nanjing Medical University (CN)
- Nanjing University (CN)
Publication Details
- Journal
- Clinical Kidney Journal
- Published
- 2025-12-12
- DOI
- https://doi.org/10.1093/ckj/sfaf394
- Citations
- 1
- Primary Topic
- Chronic Myeloid Leukemia Treatments
- Type
- article
- Field-Weighted Citation Impact
- 1.77