Integrated metagenomic and metabolomic analyses reveal tenacissoside G as a potential non-antimicrobial treatment for bovine endometritis
This study provides new insights into the relationship between uterine microbiome and metabolites in bovine endometritis, potentially leading to novel strategies for treating bovine endometritis. Furthermore, tenacissoside G exhibits therapeutic effects against endometritis induced by F. necrophorum, and could serve as a potential alternative to antimicrobials for treating endometritis. Video Abstract.
Authors
- Hailong Dong (ORCID: https://orcid.org/0000-0001-8984-9067)
- Chuang Xu (ORCID: https://orcid.org/0000-0002-0377-1439)
- Zhaoju Deng (ORCID: https://orcid.org/0000-0002-9297-7956)
- Ben Aernouts (ORCID: https://orcid.org/0000-0001-6266-3019)
- Shi-quan Zhu (ORCID: https://orcid.org/0000-0003-1384-2234)
- Yihui Huo
- Androniki Psifidi (ORCID: https://orcid.org/0000-0003-4095-1452)
- Moli Li
- Qiqi Cao (ORCID: https://orcid.org/0000-0001-6163-3256)
Institutions
- Royal Veterinary College (GB)
- Tibet University (CN)
- Animal Husbandry and Veterinary Department (IN)
- China Agricultural University (CN)
- KU Leuven (BE)
Publication Details
- Journal
- Microbiome
- Published
- 2025-12-13
- DOI
- https://doi.org/10.1186/s40168-025-02264-x
- Primary Topic
- Reproductive Physiology in Livestock
- Type
- article
- Field-Weighted Citation Impact
- 0.00