Association of Ticagrelor Metabolic SNPs With Adverse Drug Reactions in Patients With Acute Coronary Syndrome
The CYP3A5 rs776746 CC genotype is a significant genetic biomarker for ticagrelor-induced dyspnea. Pre-emptive genotyping could enable personalized antiplatelet therapy, such as alternative P2Y₁₂ inhibitors for high-risk CC carriers, to improve patient safety.
Authors
- Jingwen Song (ORCID: https://orcid.org/0000-0003-1910-9287)
- Feng Chen (ORCID: https://orcid.org/0000-0002-6831-1118)
- Junmei Liu (ORCID: https://orcid.org/0000-0003-0936-4321)
- Guan Yu Yu
- Yanming Zhang (ORCID: https://orcid.org/0009-0006-0610-9463)
- Cong Wang (ORCID: https://orcid.org/0009-0006-2448-3352)
Institutions
- Second Military Medical University (CN)
- Changhai Hospital (CN)
Publication Details
- Journal
- Clinical Cardiology
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/clc.70232
- Citations
- 1
- Primary Topic
- Antiplatelet Therapy and Cardiovascular Diseases
- Type
- article
- Field-Weighted Citation Impact
- 1.39