Butyrate ameliorates DSS-induced ulcerative colitis in mice by facilitating autophagy in intestinal epithelial cells and modulating the gut microbiota through blocking the PI3K-AKT-mTOR pathway
This study suggests that butyrate may alleviate DSS-induced UC in mice by blocking the PI3K/AKT/mTOR pathway to facilitating autophagy in intestinal epithelial cells and by modulating the gut microbiota.
Authors
- Hanhui Cai (ORCID: https://orcid.org/0000-0003-4906-8316)
- Yan Sun (ORCID: https://orcid.org/0000-0001-6471-7359)
- Jun Zhang (ORCID: https://orcid.org/0000-0003-3618-1723)
- Rui‐Fang Li (ORCID: https://orcid.org/0000-0003-1526-8512)
- Mingzhi Feng
- Drolma Kelsang
Institutions
- Zhejiang Chinese Medical University (CN)
- Hangzhou Medical College (CN)
Publication Details
- Journal
- PLoS ONE
- Published
- 2025-12-11
- DOI
- https://doi.org/10.1371/journal.pone.0337214
- Citations
- 1
- Primary Topic
- Autophagy in Disease and Therapy
- Type
- article
- Field-Weighted Citation Impact
- 1.35
Funders
- Zhejiang Traditional Chinese Medicine Administration
- Science and Technology Program of Zhejiang Province