Distribution of Somatostatin and Its Receptors in the Intestinal Tract in Healthy Patients and Patients with Type 2 Diabetes
Somatostatin-positive cells as well as somatostatin and SSTR1 mRNA expression are abundant in the mucosa through the entire human intestinal tract, and no differences between healthy individuals and patients with type 2 diabetes were observed. mRNA expression levels of SSTR2-5 are low and SSTR4 undetectable in the human intestinal tract.
Authors
- Camilla D. Wahlgren
- Tina Vilsbøll (ORCID: https://orcid.org/0000-0002-0456-6787)
- Julie Lyng Forman (ORCID: https://orcid.org/0000-0001-7368-0869)
- Sophie W Nielsen (ORCID: https://orcid.org/0000-0002-5934-038X)
- Lærke S. Gasbjerg (ORCID: https://orcid.org/0000-0002-7880-8515)
- Steen Seier Poulsen (ORCID: https://orcid.org/0000-0003-4419-4911)
- Jens Pedersen (ORCID: https://orcid.org/0000-0001-9443-5977)
- Hannah Gilliam‐Vigh (ORCID: https://orcid.org/0000-0002-6999-1872)
- Filip K. Knop (ORCID: https://orcid.org/0000-0002-2495-5034)
- Tina Jorsal (ORCID: https://orcid.org/0000-0001-6223-5284)
Institutions
- University of Copenhagen (DK)
- Steno Diabetes Centers (DK)
- Herlev Hospital (DK)
- Glostrup Hospital (DK)
- Gentofte Hospital (DK)
- Rigshospitalet (DK)
Publication Details
- Journal
- The Journal of Clinical Endocrinology & Metabolism
- Published
- 2025-12-11
- DOI
- https://doi.org/10.1210/clinem/dgaf648
- Primary Topic
- Neuroendocrine Tumor Research Advances
- Type
- article
- Field-Weighted Citation Impact
- 0.00