CXCR6 defines a distinct resident state in γδ T cells for protecting from liver cirrhosis
Liver-resident CD69 + CXCR6 + γδ T cells constitute a protective immune subset that limits fibrosis development and progression. Enhancing the function or abundance of this population may offer a promising immunotherapeutic strategy for liver cirrhosis.
Authors
- Qianyu Ye
- Yanxu Chen (ORCID: https://orcid.org/0009-0002-4608-7765)
- Jianlei Hao (ORCID: https://orcid.org/0000-0003-4600-3082)
- Zhinan Yin (ORCID: https://orcid.org/0000-0001-6524-8777)
- Yingqian Zhong
- Dongmei Ye (ORCID: https://orcid.org/0000-0003-0247-3891)
- Yifang Gao (ORCID: https://orcid.org/0000-0003-2817-9391)
- Xiaomin Shi
- Wenjing He (ORCID: https://orcid.org/0000-0002-9429-1894)
- Xiaoshun He (ORCID: https://orcid.org/0000-0001-5317-9612)
- Zhimin Zeng (ORCID: https://orcid.org/0000-0002-0417-9752)
- Zhitao Chen (ORCID: https://orcid.org/0000-0002-7054-6549)
- Xiaojun Ouyang
- Jiahao Ji (ORCID: https://orcid.org/0009-0005-0061-4728)
Institutions
- Shandong University (CN)
- Sun Yat-sen University (CN)
- Jinan University (CN)
- Second Affiliated Hospital of Guangzhou Medical University (CN)
- First Affiliated Hospital of Guangzhou Medical University (CN)
- The First Affiliated Hospital, Sun Yat-sen University (CN)
- Guangdong Provincial People's Hospital (CN)
- Guangzhou Medical University (CN)
Publication Details
- Journal
- Hepatology
- Published
- 2025-12-11
- DOI
- https://doi.org/10.1097/hep.0000000000001643
- Primary Topic
- Liver physiology and pathology
- Type
- article
- Field-Weighted Citation Impact
- 0.00