Dose-Dependent Cardioprotection of Pterocarpus indicus Extract in Rats With Myocardial Ischemia: Targeting Oxidative Stress, Inflammation, and Apoptosis
P. indicus extract confers dose-dependent cardioprotection against ISO-induced myocardial injury through dual modulation of the Nrf2/HO-1 and Bax/Bcl-2/Caspase-3 pathways, with the medium dose (54 mg/kg) identified as optimally effective and well-tolerated.
Authors
- Sun Fangyun
- Xin Fang (ORCID: https://orcid.org/0000-0001-7768-3127)
- Wen Du (ORCID: https://orcid.org/0000-0002-3361-088X)
- Chen Yichun (ORCID: https://orcid.org/0009-0001-9851-9075)
- Jin Weimeng
Institutions
- Xizang Minzu University (CN)
Publication Details
- Journal
- Dose-Response
- Published
- 2025-10-01
- DOI
- https://doi.org/10.1177/15593258251404066
- Primary Topic
- Cardiac Ischemia and Reperfusion
- Type
- article
- Field-Weighted Citation Impact
- 0.00