Amyloid‐negative neuropsychological norms: Added value in the era of biomarkers and disease‐modifying therapies
Next-generation norms (NGN) reclassify one of every five cases from cognitively normal (CN) to mild cognitive impairment (MCI).This group shows poor cognitive performance and a high prevalence of amyloid β positivity.NGN-based diagnosis of MCI predicts cognitive progression on follow-up.Results indicate that NGN improve the detection of objective cognitive impairment.NGN can inform biomarker use, therapy indication, and clinical trial design.
Authors
- Sara Rubio‐Guerra (ORCID: https://orcid.org/0000-0001-7652-8029)
- Juan Fortea (ORCID: https://orcid.org/0000-0002-1340-638X)
- Mirian Ecay‐Torres (ORCID: https://orcid.org/0000-0001-7170-6180)
- Ana Pozueta
- Ainara Estanga (ORCID: https://orcid.org/0000-0002-6616-314X)
- Albert Lladó (ORCID: https://orcid.org/0000-0002-5066-4150)
- Eloy Rodríguez‐Rodríguez (ORCID: https://orcid.org/0000-0001-7742-677X)
- Lorena Rami (ORCID: https://orcid.org/0000-0002-7411-1921)
- Laura Videla (ORCID: https://orcid.org/0000-0002-9748-8465)
- Mircea Balasa (ORCID: https://orcid.org/0000-0002-1795-4228)
- David Gómez‐Andrés (ORCID: https://orcid.org/0000-0001-5654-7791)
- Miren Altuna (ORCID: https://orcid.org/0000-0001-9709-5314)
- Isabel Sala (ORCID: https://orcid.org/0000-0002-9886-4792)
- Raquel Sánchez‐Valle (ORCID: https://orcid.org/0000-0001-7750-896X)
- Adrià Tort‐Merino (ORCID: https://orcid.org/0000-0002-5646-0482)
- Ignacio Illán‐Gala (ORCID: https://orcid.org/0000-0002-5418-2052)
- Pablo Martínez‐Lage
- Sara López‐García (ORCID: https://orcid.org/0000-0002-7888-8850)
- Carmen Lage (ORCID: https://orcid.org/0000-0003-1703-121X)
- Nuole Zhu (ORCID: https://orcid.org/0000-0002-0015-9455)
- Magda Castellvı́ (ORCID: https://orcid.org/0000-0002-0779-4988)
- Pascual Sánchez‐Juan
- Carolina Lopez de Luis
- Alexandre Bejanin (ORCID: https://orcid.org/0000-0002-9958-0951)
- Mikel Tainta (ORCID: https://orcid.org/0000-0003-0624-1211)
- Daniel Andres Alcolea (ORCID: https://orcid.org/0000-0002-3819-3245)
- María García-Martínez (ORCID: https://orcid.org/0000-0002-7556-0147)
- Javier Arranz (ORCID: https://orcid.org/0000-0003-0891-1215)
- María Belén Sánchez‐Saudinós
- Alberto Lleó
Institutions
- Universitat Autònoma de Barcelona (ES)
- Universidad de Cantabria (ES)
- Basque Government (ES)
- Hospital de Sant Pau (ES)
- Biomedical Research Networking Center on Neurodegenerative Diseases (ES)
- Vall d'Hebron Institut de Recerca (ES)
- Instituto de Investigación Marqués de Valdecilla (ES)
- Hospital Clínic de Barcelona (ES)
- Fundacion CITA Alzheimer (ES)
- Fundació Clínic per a la Recerca Biomèdica (ES)
Publication Details
- Journal
- Alzheimer s & Dementia Diagnosis Assessment & Disease Monitoring
- Published
- 2025-10-01
- DOI
- https://doi.org/10.1002/dad2.70223
- Primary Topic
- Dementia and Cognitive Impairment Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- European Commission
- Instituto de Salud Carlos III