β-Lactam dosing in critically ill children: predictors for target non-attainment
This study found an eGFR ≥90 mL/min/1.73 m2 to be associated with target non-attainment, indicating that kidney function should be taken into account when identifying individuals who may require higher dosages. These results may help identify subpopulations of paediatric patients requiring higher dosages or continuous infusion in order to achieve adequate β-lactam exposure.
Authors
- Birgit C. P. Koch (ORCID: https://orcid.org/0000-0002-1202-3643)
- Nelianne J. Verkaik (ORCID: https://orcid.org/0000-0003-2351-2669)
- Tim Preijers (ORCID: https://orcid.org/0000-0001-6953-0358)
- Alan Abdulla (ORCID: https://orcid.org/0000-0002-2158-6376)
- Roelie M. Wösten‐van Asperen (ORCID: https://orcid.org/0000-0002-2469-2131)
- Matthijs de Hoog (ORCID: https://orcid.org/0000-0002-1259-581X)
- Stef Schouwenburg (ORCID: https://orcid.org/0000-0003-1835-0749)
- Enno D. Wildschut (ORCID: https://orcid.org/0009-0005-5197-2656)
Institutions
- Erasmus MC (NL)
- Wilhelmina Children's Hospital (NL)
- Erasmus University Rotterdam (NL)
Publication Details
- Journal
- Journal of Antimicrobial Chemotherapy
- Published
- 2025-12-09
- DOI
- https://doi.org/10.1093/jac/dkaf457
- Primary Topic
- Antibiotics Pharmacokinetics and Efficacy
- Type
- article
- Field-Weighted Citation Impact
- 0.00