Circulating MicroRNA Biomarkers for Chronic Pain and Acupuncture Response: An Exploratory High-Dimensional Small-Sample Study
We present a rigorously validated framework for HDSS biomarker discovery that demonstrates modest but statistically significant predictive signal in extremely challenging conditions. This methodology is broadly applicable to other HDSS omics problems where traditional validation approaches fail.
Authors
- Incheon Kang (ORCID: https://orcid.org/0000-0003-4236-5094)
- Seung‐Nam Kim (ORCID: https://orcid.org/0000-0003-3038-727X)
Institutions
- Dongguk University (KR)
Publication Details
- Journal
- Journal of Pain Research
- Published
- 2025-12-01
- DOI
- https://doi.org/10.2147/jpr.s567154
- Citations
- 1
- Primary Topic
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Type
- article
- Field-Weighted Citation Impact
- 1.47
Funders
- National Research Foundation
- Korea Health Industry Development Institute
- National Research Foundation of Korea
- Ministry of Science and ICT, South Korea