Molecular structure of NLRP3 protein and its protective effect in sports induced arthritis: nutrition and exercise intervention

The NLRP3 protein plays a crucial role in the occurrence and development of various diseases. Research has shown that arthritis caused by sports injuries is closely related to the activation of NLRP3. This study aims to explore the molecular structure of NLRP3 protein and its role in sports induced arthritis, and evaluate the effectiveness of nutritional and exercise interventions in combating sports induced arthritis. In sports induced arthritis, NLRP3 expression is significantly upregulated, indicating its importance in the inflammatory process. Nutritional intervention showed effective inhibition of NLRP3 inflammasome activation. Stability intervention analysis shows that long-term adherence to exercise and nutritional interventions can sustainably reduce the activation level of NLRP3. Therefore, appropriate nutrition and exercise interventions can significantly reduce the activation of NLRP3, alleviate joint inflammation, and help protect joint health. It is recommended to introduce such intervention strategies in clinical practice to improve the consequences of joint injuries.

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Publication Details

Journal
Archives of Physiology and Biochemistry
Published
2025-12-12
DOI
https://doi.org/10.1080/13813455.2025.2600334
Primary Topic
Inflammasome and immune disorders
Type
article
Field-Weighted Citation Impact
0.00
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article

Molecular structure of NLRP3 protein and its protective effect in sports induced arthritis: nutrition and exercise intervention

Fangyu Wang
Archives of Physiology and Biochemistry
Inflammasome and immune disorders
article

Molecular structure of NLRP3 protein and its protective effect in sports induced arthritis: nutrition and exercise intervention

Fangyu Wang
article en

Abstract

The NLRP3 protein plays a crucial role in the occurrence and development of various diseases. Research has shown that arthritis caused by sports injuries is closely related to the activation of NLRP3. This study aims to explore the molecular structure of NLRP3 protein and its role in sports induced arthritis, and evaluate the effectiveness of nutritional and exercise interventions in combating sports induced arthritis. In sports induced arthritis, NLRP3 expression is significantly upregulated, indicating its importance in the inflammatory process. Nutritional intervention showed effective inhibition of NLRP3 inflammasome activation. Stability intervention analysis shows that long-term adherence to exercise and nutritional interventions can sustainably reduce the activation level of NLRP3. Therefore, appropriate nutrition and exercise interventions can significantly reduce the activation of NLRP3, alleviate joint inflammation, and help protect joint health. It is recommended to introduce such intervention strategies in clinical practice to improve the consequences of joint injuries.

Archives of Physiology and Biochemistry
Yichun University (CN)
Openalex Percentile: Top 64%
Inflammasome and immune disorders
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